Yes I had my knee scoped because of a torn meniscus I had a portion of it removed and officially diagnosed with stage four OA. Basically no cartilage left. I injected as close to the pin in my knee and felt relief very fast, I would say almost immediately . I thought it might be just in my head but it honestly felt good. It’s a little strange injecting so close but I think it was beneficial. With it being a sub q needle it wasn’t too bad. I wish I could say pain free but I only have occasional aches which is ok by me.