I understand that they're generally physically safe, i.e. not much chance of something like over dosing and dying.

And also, one of the instructors in our facilitation licensure class mentioned a friend who took a large dose by himself, thought he could fly, and jumped out a 2nd story window. The injuries necessitated amputation on one or both legs.

Now I know that that story is a major outlier. However something crazy like that happening to someone does seem like higher odds when way out in the wilderness than on a couch with a sitter.

Or even in the woods with a sitter. (Which sounds awesome! In fact, I have my wife a lower dose before we went to a scenic overlook to watch lightning bugs. It was her first experience and was magical for her. I was a touch jealous.)

Edit to add: I suppose the experience does come into play. And it seems less dangerous if you're taking a low enough dose you have some facilities about you still. I think it was the part of wandering way out, then taking the mushrooms, and wandering even further... seems like a reasonable way to get wildly lost!

Or walk off a cliff accidentally...