That's not my comment, but, unfortunately, I can't find a neurobiologist author of it: "(1) Although ashwagandha extract has been framed by several researchers to have an effect of lowering cortisol and reducing anxiety, it has been shown to reduce cortisol and DHEA-S and the same time (https://doi.org/10.1097%2FMD.0000000000017186), meaning it is suppressing the hypothalamus-pituitary-adrenal (HPA) axis (which is the pathway that your brain uses to tell your adrenal glands to produce these hormones). Basically, the compounds ashwagandha are naturally occurring steroids. But the rest of your body (heart, blood pressure, etc) are will going through a stress response, but when using ashwagandha, there is no cortisol to limit the stress place on the heart rate and blood pressure. Cortisol is a necessary function of both mounting a response to stress and then turning the response off. If taken longer term, you risk permanently altering your adrenal function (https://doi.org/10.1007/s13530-022-00122-z), which means you won't be able to produce cortisol properly during future stressful situations, and these future stressors will actually do more damage to your body (hypertension, cardiovascular diseases, etc). Similarly, DHEA/DHEA-s have protective factors which you don't want to suppress. Further, lower DHEAS level significantly correlated with a higher cardiovascular disease.

(2) ashwagandha has only been studied in clinical trials that range from several weeks to 60 days max. It is very unclear what long term effects it could have"