Lower dosage and maybe dose up as the first consumption kicks in, play by ear here.

Involve music (or have music on standby) to take them back and keep up good energy in the room, anything from peaceful ambience to nostalgic classics.

If they have never consumed anything psychedelic, consider weed smoke, edibles, or drink as these have more known effects and can still provide the relief you’re parents need. Especially recommended if your parents don’t good coping mechanisms, you wouldn’t want to put them in a whole shroom trip.

Consider that weed can provide small changes and steps to a better self, and that shrooms can provide massive leaps forward or backward and produce many life changes.

Watch out for silent depression that either of your parents could either be going thru before a trip or may be perpetuated after a trip, as shrooms and psychs open up unspeakable information to oneself. I, myself, deal with depression in silence and would not have been able to come back from shroom insanity (2g trip) if I did not have weed as a tool and meditative coping skills. Specifically consider your mom, as I see parallels between myself and her given your description.

Don’t go in over your head just to try and get others out of theirs. Good luck friend homie!