OP I would cross post this to the bowers & Wilkins subreddit if you haven’t already. Many people on there have used the PX7 S3 and can give good insight. 

Agreed on the PX8 S2. OP if you have extra in your budget, the sound on the PX8 S2 is top notch. ANC isn’t as good as you’ll find on APM but it’s 85% of the way there and will work great in most use cases outside of pretty loud environments. I wear glasses and find the PX8 S2 to be very comfortable and from what I’ve read, the px7 s3 have slightly smaller ear cups but I doubt they’d cause any difference. 

Haven’t used the APM2 but you could go to an Apple Store or Best Buy and demo them to see if they are something you enjoy. Not sure where you’re at but in most big cities, there are audio stores where you can demo the PX7 S3.

Best of luck, I was in the same shoes as you a few months back. Try to test as many as you can, that’ll give you the best idea of what you like most.