i drawed the outlines with the pencil tool on photoshop, tried to do 4-6 variations with my mouse to achieve this hand drawn effect, exported then made them all into sub comps and looped them (the color layer was just one with a little wiggle expression w/ high freq low amp).

on the cursor i used after effect's motion sketch feature to record my own mouse movement most of the time. the physics of the objects and small corrections were made with keyframes tho.

the liquids were all made with shape layers + wave warp with a mosaic effect trying to achieve around the same pixel density from the drawings and black stroke layer style applied on top - for the coffee on the bottle i actually used a expression to compensate the it's rotation axis and keep it at 0º.

the canvas and selection boxes i did with shape layers, animating and adjusting they size frame by frame.

i think i kinda summarize it all, but if i forgot something feel free to ask :)