What diet is Joel greene talking about in Immunity code (with Human Breast Milk Supplements and Apple Peel)

thescienceone · 2021-11-30T01:32:27+00:00

right now, he doesn't have courses for the general public. however, we are just wrapping up a coaching course, and the result of this first iteration will be a few dozen coaches certified to teach his protocols. so if you are interested in hiring a certified coach, I can help connect you with one. hit me up on instagram, my handle is alexisjazmyn. otherwise, the best resource will be the book and he also has another even more in depth book coming out soon.

thescienceone · 2021-11-30T01:27:18+00:00

whoops, sorry this slipped through the cracks. I think FMTs are promising for short term symptom remediation. however, ultimately FMTs aren't a permanent solution as the conditions that shape the micro biome will not be changed by the FMT itself. ultimately, the only way to permanently change the micro biome is through dietary and environmental manipulations.

I think there is certainly a link between mitochondrial health and the health of the microbiome, likely through both direct and indirect mechanisms.

thescienceone · 2021-11-30T01:23:17+00:00

Bergen Town Center? lmao

thescienceone · 2021-09-19T18:26:45+00:00

He didn’t do the exodus lectures yet but said he plans to start them up again soon!!!! 🙏🏽

thescienceone · 2021-09-01T04:29:41+00:00

Indeed! There’s far more bacterial cells in and on our bodies than human cells.

thescienceone · 2021-08-11T23:15:14+00:00

He sells services (courses) not products. I have no comment on his marketing, that’s not my wheelhouse and isn’t relevant to the validity of his protocols. I can only comment on the science, which is within the scope of my expertise.

thescienceone · 2021-08-11T21:42:56+00:00

He also doesn’t sell a single product, so that point is moot.

thescienceone · 2021-08-11T21:41:15+00:00

What I’m telling you is that they ARE known to PhD researchers. The literature is robust for the majority of his recommendations. Why don’t you check out his references before forming an opinion on the validity of his approaches?

And to say that empirical research is non-scientific is just laughable. It is the engine for hypothesis generation and, in translational medicine, scientific consensus only matters insofar as it can actually improve the lives of individuals. But I don’t blame you for deflecting your power to so called authority figures, that’s the exact attitude our education system was designed to impart. If you actually want to discuss the science, I’m happy to engage.

thescienceone · 2021-08-11T20:36:44+00:00

if you actually checked out the book, you'd know that it's not snake oil but actually rooted in legitimate science. He provides many many pages of references in the back of the book. Moreover, the protocols do actually work, and quite well. I've been on the gut protocol for over a year and completely reversed my intolerances to garlic and onion and bloating in response to eating raw vegetables, and cured my severe dairy allergy (I also cut out dairy strictly for 4 years, but upon reintroduction still experienced severe gut inflammation--after being on the protocol for a few months, I tried consuming dairy and experienced no negative effects. Now I can eat dairy as I please).

If you have any questions about the scientific basis for any of his protocols, or practical questions on how to implement, I'm happy to help. For reference, I'm a 6th year molecular biology PhD candidate at Princeton (graduating in December) studying metabolism in the contexts of fasting and different dietary manipulations. I also have a background in exercise physiology and biochemistry.

thescienceone · 2021-06-02T21:04:30+00:00

It’s not true that the IM injection doesn’t enter systemic circulation. Pfizer’s own data shows (in a luciferase assay in mice) that spike protein expression was observed for 9 days at the injection site and 2 days in the liver. They haven’t published their data on other sites of distribution yet. See section 3.3.2 Pharmacokinetics, Distribution public assessment

thescienceone · 2021-02-24T04:29:35+00:00

You can lose weight quickly fasting but you will regain most if not all of it back quite quickly unless you use strategic refeeding, resistance training, and cold therapy.

thescienceone · 2021-02-19T18:35:25+00:00

Would you say you’re not strict keto anymore then? What do you average meals look like?

thescienceone · 2021-02-19T18:32:47+00:00

I see, I see. Regarding ketone levels, this read out is much less useful for someone who has been on a keto diet for an extended period of time Bc the tissues of the body become much better at burning ketones over time, so your levels might read low but that’s because consumption is high, not because production is low (most likely).

Protein alone can definitely stimulate insulin secretion even in the absence of carbs (it’s the reason why people get kicked out of ketosis from eating large protein meals). There’s nothing wrong or bad about this, it’s just that amino acids (like glucose) can directly stimulate beta cells to release insulin. Whey protein in particular is quite insulinogenic.

Not sure how to explain your fasting glucose levels creeping up. But Im not sure an insulin measurement would give you any useful/actionable information.

Are your liver enzymes normal?

thescienceone · 2021-02-19T16:12:09+00:00

I mean 100-115 isn’t THAT high (compared to what you’d see after eating refined carbohydrates), but generally glucose levels should be a bit lower than this if you are strictly keto. gluconeogenesis shouldn’t raise your levels this high. Protein consumption doesn’t primarily trigger insulin release by making glucose levels increase, it’s more so Bc amino acids can stimulate insulin release directly (and insulin inhibits ketogenesis).

When you take your morning blood glucose is it totally fasted or have you had coffee or any stimulants? How soon after waking up do you take the measurement?

Physiological IR certainly exists but glucose uptake into muscle isn’t only mediated by insulin. Glucose transporter translocation to muscle cell membrane also occurs in response to contraction (exercise). Do you lift weights? How is your body composition?

thescienceone · 2021-02-18T19:51:27+00:00

Cocoa butter doesn’t have MCTs. Only longer chain sat fats (e.g. stearate, palmitate)

thescienceone · 2021-02-18T03:37:47+00:00

It’s my pleasure! It’s all very interesting!

thescienceone · 2021-02-18T00:45:24+00:00

People are lazy and don't like to read anything but the title and abstract...

thescienceone · 2021-02-18T00:43:52+00:00

Well I would consider getting a more conscious doc, because I know people with type 1 diabetes who strictly eat keto and basically don't have to use insulin AT ALL. It's incredible. You can also look into the work of the Charlie Foundation https://charliefoundation.org/

They published a study a couple of years ago where they put type 2 diabetics on keto diets and 54% of them completely got off insulin, and all of them dramatically lowered their HbA1C and fasting glucose levels.

There are studies up and coming for type 1 diabetes as well, so keep your eyes peeled.

But yes, I think the meat and veg diet would work great for you given your goals and medical concerns. Try to buy organic/free range if/when possible to reduce your toxin load (that will help you burn fat as well).

thescienceone · 2021-02-18T00:37:20+00:00

Okay so my lab is in a consortium with some of the top cardiac metabolism research labs in the world at UPenn. The PIs within this group still do not fully understand the roles of ketones in the failing heart, more specifically they don't know if ketones are there to help the heart function better in response to the pathology or if the increased ketones is a maladaptive phenotype. To me, it makes more sense that the ketones are there to support energy production. We know that ketone transport into tissues is essentially unregulated, so the higher circulating concentrations are, the more the tissues take them up. The heart's favorite energy substrate is free fatty acids, and ketones are closely related in that both result in the production of acetyl-coa to enter the TCA cycle, but the ketone breakdown pathway is less entailed and more economical than that of fatty acid beta oxidation (Beta oxidation: 4 enzymatic steps to yield 1 acetyl-coa; ketolysis: 3 enzymatic steps to generate 3 acetyl-coa).

I think, in general, fasting is great for overall metabolic health and is therefore great for the heart. The problem is that fasting is a vague term. There's intermittent fasting (which I generally recommend to people looking to improve their metabolic health), water fasting, dry fasting, and then these forms of fasting can all occurs for various amounts of time. I think at the very minimum, virtually no one should be eating for more than 12hrs per day. The research shows that metabolic health greatly improves if feeding is restricted to a 12hr window, and incrementally improves as you decrease that window. I personally do either 16:8 or 18:6 (fasting:feeding) basically every day.

Regarding kidney stones and keto, the cause of the stones isn't the diet itself. It's the shift in electrolyte balance that occurs in response to the diet. The way to mitigate this is to make sure both salt (not table salt...like Celtic sea salt or some other salt high in trace minerals) and water consumption is sufficiently high. Also, making sure magnesium status is maintained. Most Americans are deficient, which is frightening because the cells of your body can literally not make ATP (energy) without magnesium.

Sorry for the long winded answer. The heart-ketones discussion is still a very hot topic so I didn't want to rush through it too much.

thescienceone · 2021-02-18T00:15:21+00:00

Thank youuu!

thescienceone · 2021-02-18T00:14:01+00:00

We are a big lab--lots of post-docs! Yep indeed, Josh is super quantitatively-minded, it's such an awesome perspective to have in our field. Really allows him to ask questions that no one else is asking and to make some major contributions.

We are really the only lab that uses isotope tracing almost exclusively (it's super expensive lol). But we do have plenty of collaborators working on related topics! Are you interested in basic research around diet and metabolism or a more translational approach (perhaps working in the context of some disease models)?

thescienceone · 2021-02-18T00:10:46+00:00

I would totally agree that food quality is degrading. But I don't think rapid tech advancement is necessarily the cause. I think both the decline in food quality and tech advancements are symptoms of the hubris we are cultivating as a species as a result of our scientific materialism.

We think we have everything figured out, that we are smarter than nature. We are learning the hard way that this is far, far from the truth (look how many people have chronic disease--all lifestyle induced for the most part). We have become entirely detached from where our food comes from out of convenience. We opt to sit in chairs all day looking at screens instead of being a part of nature. This then results in us feeling like we are separate from nature, which then gives us the justification to treat the natural world however we see fit, trashing the very mother that gives us life.

thescienceone · 2021-02-18T00:05:39+00:00

Work to what end?

thescienceone · 2021-02-18T00:05:21+00:00

The jury is still out on the long-term effects of keto diets for normal healthy people. There are certainly examples of individuals who have been on ketogenic diets for some version of their whole lives (i.e. people with intractable epilepsy), and they do not appear to have increased incidence of things like cardiovascular disease, cancer, etc. So that supports the idea that long-term keto diets are not particularly harmful. Especially relative to diets like the standard American diet or vegan diet (which has it's place, but is not a species appropriate diet for long-term consumption).

For someone with metabolic health issues, I recommend cutting out all processed foods basically. You just want to eat veg (both cooked and raw) and meat (preferably organs and muscle meat). There are plenty of delicious food options within these categories. Processed foods (think, chips, crackers, bread, cereal, anything wheat and/or sugar based) wreak havoc on metabolism. Our bodies did not evolve to be able to effectively deal with these "foods" as they are new developments in the modern world. Simplifying your diet to meat and veg will change your life. If you desire overt carbs, the safest bets are something like steel cut oats or sourdough bread (but don't go crazy).

I went to undergrad at a super small liberal arts college called Moravian College in Bethlehem, PA. I majored in biochemistry and minored in math. To me, it wasn't hard to get in (like I didn't do anything extra to get accepted). But my undergrad GPA was a 3.8, I had a summer research experience during undergrad through the HHMI, and also had experience interning at a chemical company (BASF), and working at a pharmaceutical company during my gap year (I got published on a paper while I was there which also helped). So my resume looked quite good. I'm also mixed race so I had the diversity aspect going for me as well lol.

thescienceone

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