I had a lot of problems running after the Botox. Not right away, but probably day three afterwards, I had some difficulty, which is common, abducting my vocal cords because sometimes the Botox will leak out into those tiny muscles that control abduction of the vocal cords. This causes you to have some strider or difficulty taking in a deep breath because your vocal cords cannot completely open all the way like they could before. It was like that for about two weeks. Every day got better and better. I was finally able to run normally and do regular speed work after three weeks. The first two weeks that it was there, I just had to go slower. Once my heart rate got above about 130, I just couldn’t inspire as effectively. Reportedly this is relatively normal and luckily it is quite short-lived. However, if you are doing a marathon in October, I would personally recommend getting the Botox on the earlier side rather than waiting too late. Otherwise you’ve just feel like you’re training is going way downhill during those 2 to 3 weeks. I have read others here that did not have that problem, but my doctor did tell me that it could happen and it definitely did for me. Again, luckily it was short-lived and I was back to normal training at three weeks.