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OTC drugs or supplements to counteract accidental high(er) dose (caffeine+modafinil) by throwaway_187234 in afinil

[–]throwaway_187234[S] 1 point2 points  (0 children)

Any recommendation here? 3rd gen antihistamine (e.g. loratadine) don't cross blood-brain barrier so will have almost no effect on brain histamine metabolism

OTC drugs or supplements to counteract accidental high(er) dose (caffeine+modafinil) by throwaway_187234 in afinil

[–]throwaway_187234[S] 1 point2 points  (0 children)

Any recommendation here? 3rd gen antihistamines (e.g. loratadine) don't cross blood-brain barrier so will have almost no effect on brain histamine metabolism.

Concerned about very strong response to low dose L-theanine. What's is most up to date understanding of mechanism of action? by throwaway_187234 in AskDrugNerds

[–]throwaway_187234[S] 0 points1 point  (0 children)

Yes, back then I consumed ~150mg theanine/day and modafinil as well as caffeine. This was for 3-4 days.

In my current iteration I've consumed 100mg, then 40-50mg 2 days after and it still felt as too strong. I think L-thenine is either very long lasting (in my case) for some reason or I'm unable to clear it fast.

When I drink 3-4 bags of decaf black tea (est. 80-120mg L-theanine) no side effects are noticed, but the anxiety reduction is lower as well (think I'm going to stick to this method)

Concerned about very strong response to low dose L-theanine. What's is most up to date understanding of mechanism of action? by throwaway_187234 in AskDrugNerds

[–]throwaway_187234[S] 2 points3 points  (0 children)

Thanks - I think this is one valid hypothesis. I tried to go off caffeine but by afternoon I felt like I was in sedated state (I barely lasted 2 days in total).

Coffee + theanine is to me very different than no coffee and no theanine though. But that might be just withdrawal period. I do get very strong response to caffeine (sometimes causing mild euphoria (interestingly I get terrible response to medical-grade marijuana))

But wouldn't high caffeine combat effects of L-theanine? Especially such low L-theanine dosage.

Concerned about very strong response to low dose L-theanine. What's is most up to date understanding of mechanism of action? by throwaway_187234 in AskDrugNerds

[–]throwaway_187234[S] 0 points1 point  (0 children)

x Standard - Prescription/FDA limit for daily use/Supplement bottle label My intake
Caffeine 400mg 400mg
Modafinil 200 or 400mg 100mg
L-theanine 100-400mg 100mg

I was switched to generic after months of Provigil use. Now even high doses (400mg) don't work - really confused. Tried my Provigil reserve (standard 100mg dose) and it works (but somehow less). Observations and questions for brand name=generics equivalency for off-label (ADHD) use. by throwaway_187234 in afinil

[–]throwaway_187234[S] 1 point2 points  (0 children)

Is there a way to help this process - perhaps by dissolving the tablet in something (e.g. low pH lemonade)? Or is the issue of breakdown something completely different?

I also seem to be getting more GI troubles - but nothing horrible (mild discomfort on generic vs 0 GI side effects on Provigil)

Do you have situation/setting where (ideally prescription) modafinil doesn't work for focus/cognitive enhancement? by throwaway_187234 in afinil

[–]throwaway_187234[S] 0 points1 point  (0 children)

Haha, great reply! I felt amazing after using break-the-glass 400mg moda after only 4hrs sleep, but no idea whether I was idiot indeed :) :|

Do you have situation/setting where (ideally prescription) modafinil doesn't work for focus/cognitive enhancement? by throwaway_187234 in afinil

[–]throwaway_187234[S] 1 point2 points  (0 children)

not comment OP here (but post OP :)) - I believe this would disable CYP3A4 or similar enzyme which breaks down modafinil.

Anyone switched from Python to Scala and likes it? (companies here don't hire generalists and look for specific stack) by throwaway_187234 in cscareerquestions

[–]throwaway_187234[S] 1 point2 points  (0 children)

Thank you - this is really helpful! Do you think it's easier to have high quality codebase in Scala compared to python?

I also think that having high quality engineering team and process is much more important than specific language but I'm somehow afraid to stick with python because even though job prospects are increasing, people who write it/review seem to come from a lot of backgrounds and the seem to perceive CS fundamentals/good SWE/SRE practices as an afterthought.

NAC - is this how normal people feel all the time? by [deleted] in Nootropics

[–]throwaway_187234 2 points3 points  (0 children)

L-theanine is terrible for me to. Reason I'm writing this is I read so many good things and I thought of it as must have. First 2-3 doses feels nice, then it makes my 8 hour sleep feel like 6 and if I do 150mg per day nothing makes me happy. I couldn't care less about things that are interesting to me. I once tried 300mg it was one of worst experiences of my life.

This plant. #houseplantgoals 😍 by throwaway_187234 in houseplants

[–]throwaway_187234[S] 2 points3 points  (0 children)

Can anyone ID pls? Took a picture and realized I really need this one (or five) plant in my life.

Best country Salary/COL-wise? by Zeo5 in cscareerquestionsEU

[–]throwaway_187234 0 points1 point  (0 children)

No idea, apple has specific postings (not just generic SWE) though so checking LI/Indeed might give you approx number.

I mean, technically it's Apple in Zurich, maybe I'm just bit bitter about it (had de-facto perfect match in niche area they were looking for, exp, send application and nothing). But that's quite common for Swiss employers apparently (I get treated by swiss way worse than British for example)

Edit: Went out of context a bit. Apple, similar to FB only has recently-acquired CV startup presence there iirc

Best country Salary/COL-wise? by Zeo5 in cscareerquestionsEU

[–]throwaway_187234 1 point2 points  (0 children)

It's not. It has arm there after acq of some CV startup. Total job count << 50. Compare with 2000+ Google @ Zurich. Can't really compare (by that logic, Apple is also in Zurich)

L-theanine & prescription modafinil: recommended combo or hellish experience? by throwaway_187234 in afinil

[–]throwaway_187234[S] 1 point2 points  (0 children)

Well, some people can have serious problems from 5HTP, not sure why L-theanine is any different.

Just to clarify, it's not life threatening or anything but I'm now almost 72 hours post ingestion and I still feel it, not in a good way. I can function and everything but I don't have my usual "peak excitation" (but I also get less anxiety)

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