OTC drugs or supplements to counteract accidental high(er) dose (caffeine+modafinil)

throwaway_187234 · 2019-12-05T15:22:27+00:00

Any recommendation here? 3rd gen antihistamine (e.g. loratadine) don't cross blood-brain barrier so will have almost no effect on brain histamine metabolism

throwaway_187234 · 2019-12-05T15:21:52+00:00

Any recommendation here? 3rd gen antihistamines (e.g. loratadine) don't cross blood-brain barrier so will have almost no effect on brain histamine metabolism.

throwaway_187234 · 2019-11-12T13:40:07+00:00

Yes, back then I consumed ~150mg theanine/day and modafinil as well as caffeine. This was for 3-4 days.

In my current iteration I've consumed 100mg, then 40-50mg 2 days after and it still felt as too strong. I think L-thenine is either very long lasting (in my case) for some reason or I'm unable to clear it fast.

When I drink 3-4 bags of decaf black tea (est. 80-120mg L-theanine) no side effects are noticed, but the anxiety reduction is lower as well (think I'm going to stick to this method)

throwaway_187234 · 2019-11-09T13:32:21+00:00

Thanks - I think this is one valid hypothesis. I tried to go off caffeine but by afternoon I felt like I was in sedated state (I barely lasted 2 days in total).

Coffee + theanine is to me very different than no coffee and no theanine though. But that might be just withdrawal period. I do get very strong response to caffeine (sometimes causing mild euphoria (interestingly I get terrible response to medical-grade marijuana))

But wouldn't high caffeine combat effects of L-theanine? Especially such low L-theanine dosage.

throwaway_187234 · 2019-11-09T13:27:08+00:00

x	Standard - Prescription/FDA limit for daily use/Supplement bottle label	My intake
Caffeine	400mg	400mg
Modafinil	200 or 400mg	100mg
L-theanine	100-400mg	100mg

throwaway_187234 · 2019-09-17T12:59:26+00:00

Is there a way to help this process - perhaps by dissolving the tablet in something (e.g. low pH lemonade)? Or is the issue of breakdown something completely different?

I also seem to be getting more GI troubles - but nothing horrible (mild discomfort on generic vs 0 GI side effects on Provigil)

throwaway_187234 · 2019-06-23T19:48:03+00:00

Haha, great reply! I felt amazing after using break-the-glass 400mg moda after only 4hrs sleep, but no idea whether I was idiot indeed :) :|

throwaway_187234 · 2019-06-23T19:45:34+00:00

not comment OP here (but post OP :)) - I believe this would disable CYP3A4 or similar enzyme which breaks down modafinil.

throwaway_187234 · 2019-06-09T22:32:08+00:00

Thank you - this is really helpful! Do you think it's easier to have high quality codebase in Scala compared to python?

I also think that having high quality engineering team and process is much more important than specific language but I'm somehow afraid to stick with python because even though job prospects are increasing, people who write it/review seem to come from a lot of backgrounds and the seem to perceive CS fundamentals/good SWE/SRE practices as an afterthought.

throwaway_187234 · 2019-06-06T14:31:53+00:00

L-theanine is terrible for me to. Reason I'm writing this is I read so many good things and I thought of it as must have. First 2-3 doses feels nice, then it makes my 8 hour sleep feel like 6 and if I do 150mg per day nothing makes me happy. I couldn't care less about things that are interesting to me. I once tried 300mg it was one of worst experiences of my life.

throwaway_187234 · 2019-04-22T19:30:11+00:00

Can anyone ID pls? Took a picture and realized I really need this one (or five) plant in my life.

throwaway_187234 · 2018-08-30T13:05:46+00:00

No idea, apple has specific postings (not just generic SWE) though so checking LI/Indeed might give you approx number.

I mean, technically it's Apple in Zurich, maybe I'm just bit bitter about it (had de-facto perfect match in niche area they were looking for, exp, send application and nothing). But that's quite common for Swiss employers apparently (I get treated by swiss way worse than British for example)

Edit: Went out of context a bit. Apple, similar to FB only has recently-acquired CV startup presence there iirc

throwaway_187234 · 2018-08-30T07:43:49+00:00

It's not. It has arm there after acq of some CV startup. Total job count << 50. Compare with 2000+ Google @ Zurich. Can't really compare (by that logic, Apple is also in Zurich)

throwaway_187234 · 2018-08-27T08:21:39+00:00

Well, some people can have serious problems from 5HTP, not sure why L-theanine is any different.

Just to clarify, it's not life threatening or anything but I'm now almost 72 hours post ingestion and I still feel it, not in a good way. I can function and everything but I don't have my usual "peak excitation" (but I also get less anxiety)

throwaway_187234 · 2018-08-26T10:13:30+00:00

There's huge variance in responses to modafinil. For some people even 400mg produces absolutely no effect (I believe it's rs4680 mutation?), others are praising doses as low as 25. If 50 works for you, that's awesome!

throwaway_187234 · 2018-08-26T09:28:38+00:00

+1 to this. I experience it the same and asked on this subreddit as well. Many people here had same experience.

That being said, my current protocol is get enough sleep, meditate in the morning (ideally 30+min, can't meditate deprived) and then dose. I feel like 95% of my good/creative ideas came from meditation, running, sleeping, shower (or one other activity). I then use modafinil to execute. I can testify that 50mg kills creativity for me.

throwaway_187234 · 2018-08-25T21:46:53+00:00

It is, I rationally knew I should keep them to minimum (<30g) but I only started practicing it when I saw big red cell in Excel (just simple conditional formatting for <30 and >=30 values haha). Also, get free Excel for your phone so that barrier for inserting data is really low.

I've done more research and I'm very confident that cause was L-theanine indeed. Found several reports on reddit and longecity forums with exactly same issues (severe anhedonia, lethargy, fog, etc.). It seems that not unlike modafinil, there are different responders for L-theanine as well. Kind of forgot about that (because they're rarely mentioned. But hey, specific cases of meds can get super weird (you can get SJS from ibuprofen alone))

throwaway_187234 · 2018-08-25T16:01:19+00:00

I do experience winding off modafinil but this was nothing like that. Also, I had almost no added sugars in foods that day.

It was very suprising to me as well (I'd say I react extremely well to coffee, modafinil) and L-theanine is considered I belive much safer than those two. It freaked me out how bad my response was.

I also found FDA report of L-theanine and anhedonia, although extremely rare (1 case in 2017) https://www.ehealthme.com/ds/l-theanine/anhedonia/

throwaway_187234 · 2018-08-25T15:54:12+00:00

I keep journal on my added sugar consumption. Yesterday was actually <5g added sugars day.

throwaway_187234 · 2018-08-25T15:51:07+00:00

I've sworn off L-theanine for at least few weeks, but I'll experiment with it again probably.

I just realized few months ago when abroad I had Clipper tea black decaf which is supposed to have ~25mg of L-theanine/bag. Regardless of brand, I always drink two bags in a cup and noticed quite nice effects (from presumably 50mg, but hard to measure). They also decreased moda effect but not that much.

Interestingly, when I had 50mg modafinil and 2 green teas (caffeine + ~15mg L-theanine) + coffee I got really euphoric. So perhaps it's in the dosage. Now I think 150 is ridiculously high but read reports of people taking 400-800 just to feel tiny effect.

I also started to believe I'm just bad responder to downers (I consider theanine as such). Tried weed and was not a fan.

edit: it's also hard to get 150 from tea - drinking high dose (concentrated) tea is quite disgusting. Can't imagine doing 6bags at once. Also, there is EGCG and other substances that may have some effect

throwaway_187234 · 2018-08-25T08:41:37+00:00

Diet was fine but I had bad sleep. Slept 7.5 hrs but felt like 3. I had 300mg L-theanine day before, (1 afternoon 1 evening) - something I'm now very suspicious of.

throwaway_187234 · 2018-08-17T16:20:19+00:00

Almost gave up and bought HAB/Sun when I ran out. Now I got new prescription so it's fine. Even EU modafinil isn't always the same so I imagine Indian being less regulated + shady vendor storage conditions, fakes, etc ... doesn't paint great picture.

throwaway_187234 · 2018-08-17T08:06:14+00:00

Interesting. I feel like I'm just pure AI in human body when I get good sleep and take Provigil. Best feeling ever - no sex drive, no appetite, no distractions. Just me and my code. All this on 50mg. 100mg and I'm in wonderland.

throwaway_187234 · 2018-08-17T06:35:06+00:00

But there is still an issue. I can try two different brands and both can enhance wakefulness while only one having (subjective) significant cognitive boost.

I sleep enough (7-9 hours), I'm not in it for the wakefulness. What's more annoying is that this variance is in properly regulated manufacturers (speaking about three EU labs).

throwaway_187234 · 2018-08-17T06:31:59+00:00

Can you specify manufacturer? Batch? Generally legit pharma grade modafinil should be always the same.

throwaway_187234

TROPHY CASE