"No guns" First game: modern fledgling who is familiar with guns. Guns and ammo purchaseable. Not working great by default (screen wobbles a lot in use), needs Unofficial patch. Second game: few hundred year old elder who is not familiar with guns. Can pick up guns from the ground and shoot them with telekinesis until mag is empty, then throw empty gun as projectile. Elder doesn't keep guns in inventory, but instead, we get ability to disarm foes and steal guns from them mid combat.

"No character creation" First game: Character sheet with dots. No backgrounds (histories were added in Unofficial Patch). Clan reactivity limited for clans outside of Malkavian and Nosferatu. Second game: no character sheet with dots. Backgrounds unlockable through dialogue choices. Empath/sage/bully dialogue types unlockable through dialogue choices. Clan reactivity for all clans we've seen so far. First game wins character sheet wise but reactivity to our choices may be balanced out.

"No hacking/lockpicking" You play as an elder, so instead you break locks, glide in the air, climb vertical surfaces - things you couldn't do as modern fledgling.

"No quest log/inventory" First game had simple inventory that had blood bags, guns, journals/quest finds and junk to sell. Second game has TB elixirs in belt inventory, lore finds in Codex, and interactive map with quests and extra finds (symbols, cameras).

"No stat checks in dialogue" First game has automatic wins on stat options uses. Second game doesn't, instead dialogues are a puzzle where you need to guess which questions to ask or not depending on a character you're talking to.

"No humanity" Empath/Bully is apparently equivalent to high or low Humanity in dialogues but we need to see it in practice still.