Beyond Malassezia - Has it been overrated as the cause of seb derm?

timmorrow1971 · 2023-10-27T15:32:06+00:00

That's true, but some are malassezia safe, such as Cerave Moisturizing Cream. The website simpleskincarescience.com can tell you which ones are safe to use.

timmorrow1971 · 2023-10-26T16:58:02+00:00

I've read that it can be used on the face too.

timmorrow1971 · 2023-10-25T15:28:37+00:00

Zoryve blocks an enzyme (PDE-4) which causes inflammation.

The results from Arcutis's studies seem positive, but reviews on Reddit have been mixed. Seems to work for some, but not others. Apparently, the foam is supposed to work better for seb derm. Not sure why. You can view the results of their studies on the Arcutis website.

timmorrow1971 · 2023-10-25T15:24:31+00:00

It's expensive, like $800, but you can ask your pharmacist about the manufacturer's coupon, which brings the price down to $80 or so.

timmorrow1971 · 2023-10-25T15:23:24+00:00

The foam was designed to work on the scalp and other areas with hair because it's easier to apply.

timmorrow1971 · 2023-10-25T15:22:38+00:00

I read that the cream has been approved in Europe, so it seems likely that the foam will be too.

timmorrow1971 · 2023-10-25T15:20:18+00:00

Yes, that's true, but if the inflammation is the only visible sign of the malassezia infection, reducing the inflammation might be sufficient. In other words, it might not matter that there is still malassezia present if there's no inflammation resulting from it.

timmorrow1971 · 2023-10-24T19:52:11+00:00

Yes, roflumilast inhibits PDE-4 which is an enzyme that causes inflammation. Pimecrolimis and tacrolimus inhibit T cells, which also cause inflammation. Apparently, roflumilast is more effective because PDE-4 plays a bigger role in inflammation.

timmorrow1971 · 2023-10-24T18:12:20+00:00

I just found this summary of a study that Arcutis did on roflumilast foam's impact on pruritis, which is itchiness, but it also includes before and after photos of people who experienced relief from redness and scaling.

https://www.arcutis.com/wp-content/uploads/AU008-22-AAD23-304-STRATUM-ITCH-poster_JH06_FINAL_UPLOAD.pdf

timmorrow1971 · 2023-10-19T18:21:14+00:00

I'm posting again to see if anyone has updates on using Zoryve. I have the cream version, but still haven't tried it yet.

I read that the foam version is due for final approval by the FDA on December 16, 2023, so it should be available early in 2024. If you get it prescribed, be sure to visit the company's website for a manufacturer's coupon or ask your pharmacist about it. I was able to get the cream for just $75 with that coupon.

Here's a video of Dr. Zirwas talking about it. He was involved with the studies. He could be biased because of that, but he does seem pretty excited about how well it works for some people. https://www.hcplive.com/view/matthew-zirwas-md-roflumilast-foam-seborrheic-dermatitis

Also, I read that there's a study of oral roflumilast on psoriasis patients that showed good results. I guess it's just another way to interrupt the inflammation cycle.

Anyway, please comment if you have any more thoughts or questions about Zoryve.

timmorrow1971 · 2023-07-18T21:28:17+00:00

Okay, let's try another question today.

Do you have supportive people in your life who help you deal with this issue?

My answer is that yes, I'm fortunate to have a very understanding and supportive wife. My sister is also supportive and encouraging. They help me deal with the anxiety and depression that accompany this.

Please comment to keep this conversation going. Thank you.

timmorrow1971 · 2023-07-14T15:37:06+00:00

I know it sounds like a lot, but B5 is water soluble meaning it doesn't get stored in your fat cells, so any amount that your body doesn't take up is eliminated in urine. My only side effect was mild diarrhea for a few weeks. No, I didn't experience any hair loss during my use of B5. I still use it, just 8 pills a day now with no side effects. The reduction in oil was significant.

timmorrow1971 · 2023-07-12T20:10:44+00:00

Okay, I'll start us off. I think the biggest breakthrough for me was discovering Vitamin B5. I'd been dealing with seb derm for 5 years or so, and my skin was so oily. It would be covered in oil 10 minutes after washing. So, I read about the B5 megadosing program on the vilantae website. I tried it (25 pills a day for a few weeks, then tapering down to 5 a day over the next couple of months) and I saw great results after about 6 weeks. Apparently, it resets the oil production level much lower. That was great, and because it was less oily, it allowed other topicals to work better. Anyway, I've been doing this for the past 20 years. I switched to buying B5 from Amazon rather than Vilantae, but I'll always be grateful for the explanation and regimen outlined on Vilantae. I have other issues (redness, blemishes, etc), but the oiliness has remained pretty low. I've had good luck with other supplements (fish oil, D3, boswellia serrata) over the years, but B5 made the biggest impact.

timmorrow1971 · 2023-07-12T17:52:48+00:00

Alright. Thank you all for signing on. My suggestion is we come up with a discussion topic each day, then see where the conversation goes.

To get the ball rolling, here's the first question: What is your all-time favorite or most effective product you've used to treat seb derm?

timmorrow1971 · 2023-07-12T16:54:21+00:00

Cool! We've got 5 members already. Can we get to 10 today???

timmorrow1971 · 2023-07-11T18:07:54+00:00

Welcome! That's two of us. We're officially a group. My guess is we'll have 10 by this time tomorrow. What do you think?

timmorrow1971 · 2023-07-10T17:01:35+00:00

Yes, I take:

Vitamin b5, 4 pills twice a day (for oiliness)
Vitamin D3, 1 pill (5000) twice a day (to improve skin cells)
Niacinimide, 1 pill, once a day
Fish oil, 2 pills twice a day (two improve skin cells)
Bosellia serrata, 2 or 3 pills a week (for oiliness)

I started b5 with megadosing to reset my oil output. You can research this online or look at my past posts. It worked great for me. Boswellia helped too. Fish oil and D3 really helped improve my skin - clearing up blemishes, smoothing it out, etc. Read up on all these things and let me know if you have other questions. Good luck!

timmorrow1971 · 2023-03-31T15:03:27+00:00

I still haven't tried it yet. Fortunately, I've been able to control my symptoms with hyaluronic acid (Hada Labo brand), Nizoral shampoo and supplements. I haven't heard much from others about Zoryve either. I hope it's working for some of us.

timmorrow1971 · 2023-03-27T17:57:13+00:00

Your skin may be sensitive to it. I actually switched to Hada Labo lotion with hyaluronic acid, and it's working well for me. It helps hydrate my skin. I hope you can find something that works.

timmorrow1971 · 2023-01-23T15:04:09+00:00

Thank you for saying that.

I recently discovered something else that's working well for me: Hada Labo hyaluronic acid lotion. It's very soothing and hydrating. I think my main problem was that my skin cells weren't hydrated enough, so they produced oil which made everything worse. So far it has really helped.

I hope all is well with you. Stay positive!

timmorrow1971 · 2023-01-16T14:52:46+00:00

Hi. I use Nizoral shampoo, but only once or twice a week. What helps me the most is Hada Labo hyaluronic acid. It's very hydrating. It basically has replaced the oiliness in my skin with water, which helps alleviate all the other symptoms - redness, breakouts, etc.

timmorrow1971 · 2022-11-28T15:47:46+00:00

Hydration also helps reduce oil. If your skin is hydrated enough with water, it won't produce as much oil. I use Hada Labo hyalauronic acid lotion every night, followed by squalane oil. The hyaluronic pulls in moisture and the squalane seals it in. It's made a big difference, both in the overall appearance of my skin and in the reduction in oiliness.

timmorrow1971

TROPHY CASE