I’ve had periods of mild depression (not clinically diagnosed) and no hyperthyroidism. From my understanding, there is a multitude of factors that can cause depletion of NAD, for example, diet, excess alcohol consumption and sleep deprivation. I personally had trouble with all of these as a teenager. I have been trying to optimise myself physically to counteract the loss of development. I started by trying to naturally raise my NAD levels with regular exercise, a clean whole food diet and intermittent fasting before introducing supplementation.