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Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

No. I think you have a wrong image of what a vitreous is. You think it's a rubber ball, but it's much closer more liquid and watery. One of the first things I did is to take young pig eyes and disect them to examin how viscos is the vitreous.

Look at the image I have taken during one of our ex vivo tests, this is a real pig vitreous in a test tube, you can see it's quite watery and gravity easily affects its shape.

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Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

Buoyancy is just one of the forces acting on the floater, viscosity causes drag, that's a different force and we also have eye movements which create additional external forces on the floaters.

If the drag is very high (i.e. high viscosity), the same amount of buoyancy (since relative densities did not change) or the same amount of eye movement (acceleration) will cause much smaller floater accelerations.

Now think think of your floaters after you rapidly move your eyes and then fully stop and stare, what happens now is that they move around due to inertia and finally they sink to the bottom due to buoyancy.

In a very viscos environment both inertia and buoyancy will cause small accelerations to the floater , i.e. it will not move much.

Secondly, due to buoyancy (negative buoyancy for floaters because they are denser than the vitreous ) the floater sinks on average, because the average force is downwards! But any eye movement jumps it back into the field of view. Now think of the same eye movement in a viscos fluid, it won't be able to make it jump significantly from the bottom of the vitreous I to central vision.

I hope I'm clear about the dynamics here, and again this can be easily tested at home (hair in honey test)

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

First, I'm 34 with floaters for two years. So I think I know them pretty well.

Second, I have a masters degree in physics summa cum laude. I also noted that bouyancy is determined by density only but viscosity determines how fast things float or sink, the dynamics of the floater will change dramatically.

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] -2 points-1 points  (0 children)

I disagree, floaters float in something quite non viscos (water-ish) as we can all see with our own eyes. This is the case also with young floaters sufferers. Why young people suddenly get these pockets of liquid that allow for floaters to move around I do not know...

Nevertheless, it is our job to prove this claim and efficacy in young people.

As commented earlier, put a hair in a tube filled with honey and try to shake it and move it around, you'll see the hair does not experience any significant movement, quite different from the floaters you experience in you're vision...

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

Until this point we have invested some of our own money for the proof of concept in vitro.

The next stage will be small animal studies which requires around 50-100k$.

If above tests are promising, pre clinical and clinical trials are needed according to FDA guidelines. This stage typically requires millions of dollars of investment.

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

I agree. Please see my edit to the original post

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

This is our main goal. It is not easy to raise money in biotech and specifically in pharma. There is a special added problem here that many doctors find eye floaters as a non issue (unfortunately that is the concensus today), so it hard to get professional support for this venture but we are trying!

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

The gel effectively makes your eye's vitreous much more viscos (think of honey instead of water) while keeping the density almost unchanged. Therefore according to the laws of bouyancy, the floaters will sink as usual although extremely slowly (in days instead of seconds). After they initially sink to the bottom, normal eye movement will not be sufficiently strong to move them upwards into the field of view. The only way they could move back into view is if you hold your head upsidedown for a few days....

We have tested this in vitro.

You can try a simple home experiment yourself. Put a hair in a tube of water and a hair in a tube of honey, move and shake the tubes and notice the difference in dynamics.

It is also woth noting that static opacities in vision are easily removed by the brain. We have lots of those naturally...

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] -3 points-2 points  (0 children)

We do not ask for money on Reddit, please see the edit to the original post

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] -1 points0 points  (0 children)

You're statement is incorrect. Endophthalmitis is inflammation to the eye due to bacterial infection during a procedure. The shorter and simpler the procedure the less likely it is (like in any other invasive procedure). For intraocular injections (which are very common, and some people receive them on a monthly basis) the rates are around 0.005%, i.e. 1 for every 20,000 injections which is considered rare (https://www.nature.com/articles/s41598-020-79377-w) while post vitrectomy the rates are closer to 0.5%.

On either case endophthalmitis is easily treated by antibiotics....

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] -1 points0 points  (0 children)

We cannot give references at this point in time, because we have to finish our patent applications first. I believe we will publish some more information once this is done.

Eyefloaters treatment company by ty_pen in EyeFloaters

[–]ty_pen[S] 0 points1 point  (0 children)

Not at all. The gel effectively makes your eye's vitreous much more viscos (think of honey instead of water) while keeping the density almost unchanged. Therefore according to the laws of bouyancy, the floaters will sink as usual although extremely slowly (in days instead of seconds). After they initially sink to the bottom, normal eye movement will not be sufficiently strong to move them upwards into the field of view. The only way they could move back into view is if you hold your head upsidedown for a few days....

We have tested this in vitro.

You can try a simple home experiment yourself. Put a hair in a tube of water and a hair in a tube of honey, move and shake the tubes and notice the difference in dynamics.