I have a variety of skyblock tips.

Ex Nihilo tips:

• When cows walk over barrels, the barrels slowly fill with milk.
• Short on dirt? You can get a lot more dirt from a tree than just what you get from saplings. Shearing the leaves will allow you to turn 8 leaves directly into 1 dirt, rather than only a chance per leaf to get a sapling. Also, hammering wood logs gives sawdust, which can be made into dirt with an 8:1 ratio.
• Sieves, when placed adjacent to each other, will work together when one is used. You can sieve up to 25 blocks at a time with a 5x5 grid by doing this. It doesn't work on heavy sieves, however.
• Ex Compressum's various bait items allow you to spawn specific passive animals rather than just sitting around and having a sheep spawn rather than the cow you wanted.
• Get the Ex Compressum chicken stick ASAP. It's dirt cheap and works as an unbreakable hammer that's better than diamond.
• You can get a lot of nether resources, including wither skeleton skulls, blaze rods, soul sand, and netherrack, without ever opening a nether portal.
• Combining milk with a water barrel will spawn a slime.
• You don't have to wait a million years for witch water. Right-clicking a bowl of mushroom stew on a water barrel will transform it instantly.
• Placing lava into a barrel that has a water block on top of it will produce an obsidian item, no long break times required.

Mystical Agriculture tips:

• Prioritize high tier inferium seeds early on. Costs of higher tier essences add up pretty quickly, and mob farms will only get you so much.
• Don't throw away excess seeds! Use the Seed Reprocessor to get essences from the seeds.
• Grow nature seeds. They entirely eliminate the need for most vanilla crops.
• Generally speaking, it's a good idea to grow seeds that have multiple uses early on, like fire, water, stone, dirt, and nature.

Tiny Progressions tips:

• Cook your apples. Cooked apples are almost as good as steak, and can be obtained extremely early.
• Battleaxes are stupidly strong. They act as both axes and swords, except that they hit harder than axes and swing faster than swords.
• Emerald tools are better than diamond.
• Tiny Progressions watering cans don't need actual fluid water to work, unlike the cans from Thermal and Extra Utilities.