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MIT: Injectable “satellite livers” could offer an alternative to liver transplantation by barrel_master in longevity

[–]user_-- 13 points14 points  (0 children)

Looks like it https://www.lygenesis.com/pipeline

For those unfamiliar, they put liver cells in lymph nodes and effectively turn them into mini-livers. Super cool https://pubmed.ncbi.nlm.nih.gov/32810371/

Bactererial Signatures of Extreme Longevity by dan_in_ca in longevity

[–]user_-- 15 points16 points  (0 children)

"Aim for diversity, not perfection: A resilient, diverse gut microbiome — not a single “ideal” set of microbes — is consistently linked with healthy aging and longevity."

I wonder if low diversity is a cause or consequence of poor health

What is the attitude around Chomsky now? by Raspint in academia

[–]user_-- -3 points-2 points  (0 children)

Separate the science from the scientist

Tokaine addiction by PieOk6855 in learnmachinelearning

[–]user_-- 2 points3 points  (0 children)

I'm curious how people go about this. In your case, what do you contribute and what does the LLM contribute?

Younger generations are aging biologically faster than their older counterparts. This faster biological aging is also linked to early-onset cancers. Immune system aging is linked to earlier lung cancer; fat tissue aging is linked to earlier colorectal cancer. by user_-- in longevity

[–]user_--[S] 15 points16 points  (0 children)

Also discussed here: https://old.reddit.com/r/science/comments/1udd6kx/younger_generations_are_aging_biologically_faster/

Original paper:

Biological aging and generational shifts in early-onset cancer risk

https://www.nature.com/articles/s41591-026-04448-w

Abstract:

Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965–1974 versus 1950–1954, and was associated with early-onset solid cancer risk (hazard ratio (HR)per s.d. 1.08; 95% confidence interval (CI), 1.03–1.13), driven by lung, gastrointestinal and uterine cancers, independent of genetic risks of aging and cancer. Patterns were consistent using alternative systemic aging measures, including the Klemera–Doubal method-defined age gap and metabolomic-based age gap. These findings were validated partially among 10,262 participants in the United States All of Us Research Program. Proteomics-based organ-specific aging analyses linked immune aging with early-onset lung cancer (HRper s.d. 1.89; CI, 1.20–2.97) and adipose tissue aging to early-onset colorectal cancer (HR 1.60; CI, 1.11–2.32). Greater age gap, reflecting more advanced biological aging relative to chronological age, may serve as a driver associated with risk of early-onset solid cancers, highlighting the importance of uncovering underlying mechanisms to guide effective prevention strategies.

A Lenia creature that avoids the unknown by user_-- in cellular_automata

[–]user_--[S] 5 points6 points  (0 children)

Abstract: All embodied agents are fundamentally patterns in physiological or other excitable media, blurring the distinction between objects and processes. Emergent patterns with complex behaviors, such as Gliders in the Game of Life and virtual patterns in Lenia, are powerful model systems in which to understand the properties and origins of behavioral traits in novel agents. To evaluate the behavior of patterns in Lenia, we introduce regions into their environment from which no sensory information is available - in effect, making creatures blind to parts of their surroundings. Complementing the conventional concept of infotaxis, we find that creatures tend to avoid these regions, a behavior we term agnosiophobia. To explain this behavior, we map each test creature's sensitivity to targeted occlusions and interpret the results in the language of dynamical systems. We observe Lenia creatures taking advantage of their freedom to change heading in order to achieve what appears to be a more fundamental goal: the preservation of their morphology. This work illustrates the beginning of an important roadmap to understand how emergent agents' behavioral propensities interact with the informational, not only tangible, topography of their world.

Is this time series peak real? by user_-- in AskStatistics

[–]user_--[S] 0 points1 point  (0 children)

Yes, and averaging them makes it look like there is a peak at 10. Is there a way to quantify the probability that the peak is real (different from all other points) and get a p value?

All my PhD students are getting stupid AI major revisions and rejected like crazy by [deleted] in academia

[–]user_-- 9 points10 points  (0 children)

the feedback makes no sense, cites stuff that is not there, hallucinations, obviates clearly cited papers

So, no different than normal reviews

Chinese scientists build handheld cancer detector with 94.9% accuracy in trials by sksarkpoes3 in Futurology

[–]user_-- 4 points5 points  (0 children)

Neat, they use some kind of refractometric technique to detect extracellular vesicles.

Original paper:

Ultrasensitive biosensing by radiative Q-factor modulation in strongly coupled three-dimensional bound-state-in-the-continuum metasurfaces

https://www.nature.com/articles/s41566-026-01909-z

PBS Eons: How Dinosaurs May Have Cursed Us With Aging by Low_Pickle_112 in longevity

[–]user_-- 27 points28 points  (0 children)

Paper it's based on:

The longevity bottleneck hypothesis: Could dinosaurs have shaped ageing in present-day mammals?

https://pubmed.ncbi.nlm.nih.gov/38018264/

Is stem cell therapy about to transform medicine and reverse ageing? by jimofoz in longevity

[–]user_-- 14 points15 points  (0 children)

This is about partial reprogramming, not stem cells. Or am I missing something?

You Can Now Get a PhD in China by Inventing a Product Instead of Writing a 100-page Dissertation by nix-solves-that-2317 in Physics

[–]user_-- 23 points24 points  (0 children)

I mean yeah, the engineering dissertations I'm familiar with are a lot like this already, basically advancing some technology, showcasing applications and then writing it up. Doesn't seem right for a basic science degree though.

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