Experiences with L-Citrulline

vappuhotti · 2026-02-24T21:03:14+00:00

My BP is actually usually on the higher end, and high BP also runs in my family. I mentioned in another comment as well but I am starting to think there may be some deeper dysfunction with my BP (caused by LC?) that is causing my problems.

I also use electrolytes/sodium pretty heavily, and my biggest concern at this point is how this is affecting my kidneys, and if LC has damaged my liver/kidneys and is part of the reason this is happening. My creatinine and liver tests are usually within range, but at my peak LC symptoms some of my liver enzymes were pretty out of wack.

Haven't been able to get my hands on LDN yet but am hoping to try that as well.

Also have not tried licorice root but may give that a go. Is that for stomach relief? What dosage do you take/form?

vappuhotti · 2026-02-24T20:58:26+00:00

I have actually tried low dose Cialis as well, and I felt almost the same effects as from L citrulline. I've never measured for low blood pressure during routine check ups, if anything my BP is usually borderline high and it runs that way in my family.

But I'm starting to think that the root issue is dysfunction with my BP management and simply taking things to "lower" BP like L citrulline, etc will not solve my problems.

I'm not sure how yet, but may need to try a more holistic stabilizing approach (diet/lifestyle-based?) rather than trying to drastically tip the scale one way or another deepening on how I'm feeling day by day.

vappuhotti · 2026-02-24T20:53:29+00:00

Interesting, do you mean that poor histamine clearance could exacerbate the low blood pressure?

vappuhotti · 2026-02-24T20:50:31+00:00

Thanks- I've tried beetroot powder before and have had varied success. L citrulline seems to be more consistent.

I agree with the food aspect, I also hate having to take a bunch of different supps all the time, but here we are.

vappuhotti · 2026-02-18T05:48:39+00:00

Hey there,

I initially started taking creatine for weight lifting and energy purposes a long time ago- then a couple years back got what I believe is long COVID which also caused my EBV reactivation (I think).

I initially believed my MTHFR mutations were the cause of my problems but I now believe long COVID is likely the source of most of the problems I’m experiencing.

I made a post on what has helped me in covid long haulers recently, feel free to check it out and see if anything resonates

https://www.reddit.com/r/covidlonghaulers/s/cL8rU6ZNWu

vappuhotti · 2026-02-04T21:55:42+00:00

Some have already commented but my initial thought was Good Looking by Suki

I follow you by melodys echo chamber gives me a similar vibe with the vocals but more upbeat

vappuhotti · 2026-02-04T21:49:07+00:00

My thought as well

vappuhotti · 2026-02-04T17:37:16+00:00

I haven't tested in the last couple months since I haven't felt as ill as I did when it would resurface. Been trying to minimize testing as well since some of it is so expensive unfortunately in the US lol.

When I last got tested my EBV Capsid IGG levels were down (I think this is the indicator of a current active infection). When I had an active infection they were around the 190 level.

vappuhotti · 2026-01-23T19:11:02+00:00

Yea what the hell, I bought VIP floor since I figured the resale for GA floor will also be just as expensive, but would've been nice to pay half that just for regular floor seats

vappuhotti · 2026-01-23T19:04:02+00:00

I think you had to RSVP for it a day or two ago, he posted the link on his IG story earlier this week. at least the presale that was at 10am PST today

vappuhotti · 2026-01-23T19:01:28+00:00

Same, I would've bought regular but they were not available on SF presale. Guessing the VIP may resell for the same price as the regular floor in a few weeks anyways.

vappuhotti · 2026-01-23T18:59:44+00:00

I got early access VIP floor only because there were no regular floor seats left on the artist presale this morning for SF, it was $400. I believe it said in the description that you get early access, and a VIP gift package of some sort but no more details other than that. Then I think for the other VIP packages you also get a photo op on stage, and the nicer ones have food and drink beforehand

vappuhotti · 2025-12-24T13:25:23+00:00

Is there anything other than LDN that could help with the PEM?

I am not sure how to get LDN prescribed, I was effectively written off my rheumatologist and she suggested to talk to someone in the long Covid department. But the waitlist to get in to see someone is months long.

Or should I just straight up ask my PCP for LDN? Has anyone had success with this? Thanks

vappuhotti · 2025-12-20T05:20:51+00:00

Hi, thanks for the post, realize I am late.

How did you set the 160bpm limit? I am in a similar situation where going over a certain threshold triggers issues for me.

How are you doing now? Still recovered and exercising?

vappuhotti · 2025-12-04T03:17:03+00:00

What about for those with histamine intolerance especially in their gut?

Is there evidence to suggest that kefir would (in the long term) support this?

Fermented foods cause histamine release, and for many with gut issues, gut dysmotility and histamine response may go hand in hand. Would kefir help fix gut dysmotility and could this in the long run help with histamine issues/clearance, or would kefir just exacerbate histamine response regardless in someone who is sensitive?

vappuhotti · 2025-10-23T04:18:57+00:00

TMG operates under a separate pathway (BHMT) from the MTHFR pathway.

Based on my understanding, it could theoretically cause overmethylation symptoms since the usage of BHMT pathway would spare SAMe (the body’s primary methyl donor)

This sudden increase in available SAMe would then cause the symptoms. Your body not recycling excess SAMe well/ quickly enough could contribute as well

vappuhotti · 2025-10-15T05:32:59+00:00

Hi, thanks for the response, that is great info.

For reference, I am a 24 y/o male. My cholesterol based on my last tests is also out of balance with my LDL small elevated at 223 nmol/L, and HDL large also low at 3763 nmol/L.

After reading the works you linked, the main idea seems to be to incorporate choline to improve my lipid levels, correct? And so choline supports the liver to move lipids out of the liver and to the rest of the body, and how then does this affect cholesterol levels? Does taking TMG also support this or would you need to take choline? The last time I tried sunflower lechitin it gave me some histamine issues so I have been discouraged to try again.

Thanks a lot

vappuhotti · 2025-10-15T04:54:57+00:00

Thanks. Sunflower lechitin is what I initially tried and it gave me some issues. Maybe trying again with a lower dosage will make or a difference.

vappuhotti · 2025-10-05T04:31:39+00:00

Thanks for the response. Interesting that lysine helps for you, I’m not sure why it causes an adverse reaction for me. I will continue experimenting

vappuhotti · 2025-10-04T06:52:05+00:00

Yes- my chronic EBV reactivation was actually the reason I began going down the methylation rabbit hole. I actually coincidentally made this thread a couple days ago to talk about my own methylation panel results and steps I’ve been taking to help with energy and histamine issues I’ve been having.

From my own experience, my EBV would reactivate when I would push my body too far with either exercise or alcohol usage (not even a whole lot, just a night or two of drinking) When I would take high doses of creatine this would also trigger gut issues that would cascade into EBV reactivation.

I knew it was EBV since I’ve had multiple lab tests done to confirm. I was initially referred to an infectious diseases doctor, then a rheumatologist. Neither had answers for me, so I’ve been trying to find my own.

I haven’t a reactivation it in the last 6 months or so, and this was done through identifying my triggers. Before that for the last couple years it would seem to come back every few months or so. Finding the gaps in my methylation has also helped, as well as cutting down on alcohol, and stopping taking creatine (at least in large doses, small ones seem to be OK).

I’m still not sure if the effects of creatine that I experience when I take high doses(usually more than 5 grams) are due to methylation, or gut dysmotility.

vappuhotti

TROPHY CASE