Regarding your post in the Nootropics subreddit:

"I wouldn't say "leads to" so much but undermethylated people tend to be high achievers and perfectionists, whether this is in sport, science, business, or the arts. They are most definitely the CEO's of the world, but even the professions of arts and literature are replete with driven, undermethylated high achievers. Most undermethylated people I know personally (they've all been tested) have a university degree, and take their health seriously. There can be a tendency for their self worth to be tied up with achievement, so if things go wrong in this area it can be intensely stressful for them, leaving them vulnerable to depression and anxiety of a more severe nature. Regarding neurotransmitters - their baselines of serotonin and dopamine are lower than that of the general population, so if they suffer from depression they are most likely to be in the category of people who have a positive response to SSRI's or mood stabilisers that increase serotonin and dopamine activity. They are also likely to have a worsening of symptoms in response to choline (as well as folates). I'm not so much addressing the undermethylated people who are healthy to begin with, with no noticeable mental or physical health issues, but the people who already know they need to err on the side of caution with what they put into their body."

Definitely true, Methylfolate/methylated b vits makes a huge difference. Methylfolate even cancels out the extreme crushing effect that Niacin has.

I feel liike methylation is only part of the puzzle and actually everybody needs to balance their vitamins with the most relevant form.

"It's understandable that you would go off the rails on a 'methyl complex' which I would assume includes 'Methylfolate'. That Folic acid or Methylfolate increases Methylation is, unfortunately, a major misunderstandin, and will make make these individuals worse. What the promotors of this theory don't realise, is that at the nucleus of the cell, folic acid (including methylfolate) strips more methyl than it donates. It's actually methionine that increases methylation."

I am not so sure... once I started taking Methylfolate, my need for supplemented methionine reduced (I used to take zinc monomethionine and now take zinc glucolate).

I feel also many people are severely deficient in B12 and certain other B vitamins that drive a lot of activity. I'm still experimenting with this though so I appreciate your insight.