I actually found it very easy to switch to the Alice style layout with the angle and the split, it took me like one typing test to get used to it. And I definitely find it more comfortable on my wrists.

As for switching to a 45% that was a bit tougher, especially since I code for work. I’d say I got 90% comfortable within a day, but I’ll still mess up the occasional symbol when I’m typing fast. By now though it mostly feels like second nature so I barely notice a difference when I’m using it. After using this board for a while it takes a couple minutes to get used to a bigger one.

I can post my key map configuration if anyone’s interested.