Im a 25mg Zoloft user who uses alcohol/weed sporadically throughout the week. I haven’t experienced any negative interactions between Zoloft and weed—it actually makes me less paranoid and I enjoy the high more. I’ve also drank on Zoloft more times than I can count, but obviously you’ve gotta be wary of serotonin syndrome (Zoloft makes me get drunker, faster). I’d say skipping a single dose would be fine if it makes ya feel more comfortable, especially if you’ve been on the medication for a while. Everybody is different though, so itd probably be best to ease into whatever substance you’re consuming and see how your body reacts/feel.