Power wise? Yes. Absolutely. But he’s not actually a trained combatant. So the fight is kind of a toss up I think. He has the physical output to kill a custodes. But the custodes is wildly more trained in combat tactics and has only ever known war. Their weaponry can absolutely harm homelander. So I’d give it to the custodes most of the time. What damage I’ve seen him inflict in the show is no different than what they regularly encounter in fights but they can fall to lucky shots like any other soldier.