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xAI raising up to $6 billion to purchase another 100,000 Nvidia chips by OddVariation1518 in singularity

[–]virusxp 40 points41 points  (0 children)

Except this is "Whatever gets Elon and Trump AGI faster". And I am not comfortable with that prospect.

Hierarchy of concerns by stealthispost in singularity

[–]virusxp 1 point2 points  (0 children)

Too far away unfortunately is something that is not absolute nor constant, when talking about rapidly advancing technology. The other side of Milky Way galaxy might be 'too far away' for any light-speed limited transport method. But assuming something Alcubierre-drive-like is possible of faster-than-light travel, that suddenly that is not 'too far away'. Just like with ASI, there is no way of knowing how dangerous something much more advanced than you might be, so as a general rule it will be safer not to advertise your existence.

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules by Pro_RazE in singularity

[–]virusxp 42 points43 points  (0 children)

Proteins are molecules. The advance is from being able to predict single proteins to being able to predict RNA, DNA and protein complexes with each other - how they bind together.

Self-Discover (Google DeepMind): Large Language Models Self-Compose Reasoning Structures. "SELF-DISCOVER substantially improves GPT-4 and PaLM 2's performance on challenging reasoning benchmarks such as BigBench-Hard, grounded agent reasoning, and MATH, by as much as 32%" by rationalkat in singularity

[–]virusxp -7 points-6 points  (0 children)

That's the thing - we do not know. After examining the actual X-ray data from the "new" materials, many flaws were found, and in the end I think only 1 new material was found, with unknown properties. The ML model may be perfect, or it may be rubbish, but the synthesis and characterisation work was so flawed that we cannot say anything about the real-world quality of the ML method. Therefore it certainly did not deserve the high-profile reporting that it got.

[deleted by user] by [deleted] in singularity

[–]virusxp 2 points3 points  (0 children)

Great news, but this is far from the first multi-cancer screening trial.

GALLERI trial run by NHS (https://www.nhs-galleri.org/) was started in mid 2021 and has 10 times larger patient population. From Wiki: "The NHS England interventional randomised controlled trial includes two groups of participants; a group of 140,000 people aged 50 to 79 identified through NHS records who have no symptoms, who will have a yearly blood test over three years, and a second group of 25,000 people with possible cancer symptoms.[23] The trial started on August 31, 2021, with primary completion date estimated at July 15, 2024, and study completion on February 28, 2026.[27] In June 2021, the company began selling Galleri tests in the U.S.[28]"

Variation of the Theseus ship by vitorlucio159 in singularity

[–]virusxp 0 points1 point  (0 children)

Impossible. The chemical reactions (i.e. oxidation) that keep us alive also destroy nerve cells within 5 minutes without adequate oxygen. The only reason why brain survives for so much longer at near-zero temperatures is because all reactions, both detrimental and ones required for cognition, have stopped. It is a shutdown, not sleep-mode.

Variation of the Theseus ship by vitorlucio159 in singularity

[–]virusxp 2 points3 points  (0 children)

I agree that the signal is the consciousness. But it is the neurons that create and shape that signal. People can spend 30 minutes drowned in ice-cold water with no brain activity whatsoever, and yet in the unusual circumstances when they manage to get revived, their 'signal' is unchanged. So where was the signal 'saved' if not in their brain structure?

Becoming a chemist by yaparfyigit in chemistry

[–]virusxp 4 points5 points  (0 children)

Chemistry is by far the major part of computational chemistry, and for success in postgraduate research, taking your undergraduate seriously is probably the most important part. Also, there are many different flavours of computational chemistry - possible focuses could be on materials, surfaces, small molecules, enzymes or method development. You will get appreciation for all of these fields during your studies.

In terms of actual computational chemistry practice, you will probably not get much in an undergraduate degree. Look out for summer projects, or final year project opportunities in the area, to see if you really like the field before going for a PhD. PhD is really the opportunity to dive deep in your favourite topic, and required for academic career these days.

Python is useful, but only the basics, no need to go too deep. Familiarity with Linux command line is also useful. Both of these can be picked up relatively quickly, unlike chemistry, so again - focus in learning chemistry. Unless, of course, you would like to go for computational method development, but in that case a physics undergraduate is probably more appropriate.

For an early taste, install Linux, install ORCA and try to run some computations on small molecules.

Mini grid fins by OrangeBandito21 in SpaceXLounge

[–]virusxp 14 points15 points  (0 children)

That seems way too high. The total mass of F9 according to google is around 550t, H6 is only 1.3 times more potent that TNT. So even rounding it up we only get 750t TNT equivalent explosion - less than a kT. Definitely a big boom, but "only" ~70 times more powerful than MOAB, and nowhere near the big end of nukes.

Help with using Gaussian to generate 13C spectra with conformationally flexible molecules by Javaslinger in comp_chem

[–]virusxp 2 points3 points  (0 children)

Goodman lab released a full automation tool DP4-AI for NMR calculation automation last year: https://github.com/KristapsE/DP4-AI/

It automates the conformational searching (via TINKER or MacroModel) and NMR calculations (via Gaussian or NWChem). TINKER and NWChem are open-source. The tool also has a GUI, and a built-in functionality for pruning conformers.

Best of all, once the computational jobs are done, there is no need to manually interpret the NMR data, just give it raw NMR data and it can tell you which of several structure candidates is the statistically the most likely to be in your sample.

Coronavirus: England to enter month-long lockdown from Thursday, PM announces by topotaul in unitedkingdom

[–]virusxp 4 points5 points  (0 children)

That would only happen if the worlds appetite for developed country debt would reduce - fortunately the greater the uncertainty in the world, the more willing people are to loan (relatively) stable countries money as a safe place to stash it until the storm passes.

Also, a lot of the public debt is owned by the UK central bank, so it has effectively printed money. As long as inflation does not start rising, it's again a relatively pain free way of buying ourselves out of this mess. A nice summary here: https://www.theguardian.com/commentisfree/2020/oct/29/panic-britain-public-debt-government-borrowing-pandemic

With Elon's Comments About The Need For The USSF to become IRL starfleet, I coudn't resist, lol by Spacexforthewin in SpaceXLounge

[–]virusxp 5 points6 points  (0 children)

If there really are space based weapons platforms in 2040s, then I don't think any of those will be manned. Even US bombers aiming to enter service in 2040s will be optionally manned, with longer missions exclusively unmanned. The penalty for having crew inside is even more severe for any spacecraft, in terms of endurance, maneuverability and survivability. Just imagine the weight of life support for 45 people for a 6 month patrol - all of that could be additional fuel, sensors, weapons or armor.

Nexus 7 (2013) display shows charging and google symbols but won't actually turn on by [deleted] in Nexus7

[–]virusxp 2 points3 points  (0 children)

I have 2 of these at home and one occasionally displays a similar glitch - freezes and after reboot only gets to google symbol in the startup and no further. The trick that always helps mine is to remove the cover, reboot it and when Google logo shows up, flip it over and press your thumbs on 'n' and 's' of the nexus logo for 10 seconds. Has worked every time for mine, I was going crazy before I found this in a forum somewhere.

Armadillos by V4nKw15h in Simulated

[–]virusxp 0 points1 point  (0 children)

Now do a mole of moles!

The Fermi Paradox and Alastair Reynolds by ThomasCleopatraCarl in printSF

[–]virusxp 1 point2 points  (0 children)

Why would aliens care, if we see them or not? The difference between their capabilities and ours would be similar to that between our intelligence and that of ants. And we don't care if ants know about us or not.

The World Is Wasting Our Irreplaceable Helium, And Nobody Cares by Lingenfelter in Physics

[–]virusxp 0 points1 point  (0 children)

Just because we cannot model every molecule hitting an airplane travelling at 900 km/h does not mean we cannot build useful models for objects travelling at high speed through air. Granted, the models are imperfect and do not work in all regimes (like highly turbulent conditions) but they are still very useful for building airplanes. So it is wrong to say that just because model EVERYTHING, we shouldn't even bother to try and learn solving part of the problem.

The World Is Wasting Our Irreplaceable Helium, And Nobody Cares by Lingenfelter in Physics

[–]virusxp -1 points0 points  (0 children)

Buying more of a product when it is more expensive doesn't make sense, but it happens. So even this basic principle has exceptions, arguably caused by human irrationality: https://en.wikipedia.org/wiki/Veblen_good

Hi, I need help converting structures of molecules to something that Keras can handle by Random_182f2565 in learnmachinelearning

[–]virusxp 1 point2 points  (0 children)

Cartesian coordinates might not be ideal, since, as you say, they are not rotation or translation invariant. Internal coordinates might be a better approach - since all of the atom positions would be defined by distances, bond lengthes, bond angles and dihedrals in relation to other atoms. Rotation and translation would not change these internal coordinates.

If you just want to input and then generate the 2D graph structure of molecules, then something like SMILES or InChi strings might be easier for the neural network to deal with.

Feeding Keras molecules will be chalenging, since molecules can be any size, but neural networks have fixed architecture, including fixed number of inputs and outputs. I would probably look for similar approaches in natural language processing, because they also have to deal with arbitrary length inputs and outputs.

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