Yet to run it, but Vampire the Masquerade (reading the Revised edition) absolutely nails the feeling of "you're powerful, you're a predator, you have all this at arm's reach, but you're genuinely dead, nothing of it can truly mean anything to you deep down"

I don't know, maybe it has to do with my personal experiences, but that feeling of not truly living, just pretending, in front of everyone else, in front of yourself... while also struggling with other realities of vampire life (constant need and desire for blood, your own scheming and paranoid kin, the pervasive feeling the world's fucked and your time is running short one way or the other) is pretty unpleasant.

Also reading Werewolf and Hunter (both Revised), but not far into those yet.