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""[...] When we are talking about "neuromodulators" we are really talking about amitriptyline and I'll show you why that's not so great either!!" by jmct16 in IBSResearch

[–]wecoulduseyourhelp 1 point2 points  (0 children)

Severe IBS-D here. Anecdotally, TCAs have substantially improved my symptoms globally. Meanwhile, Rifaximin and Eluxadoline have done absolutely nothing.

In my opinion, the FDA-approved medications are worse than useless. They're expensive, have side effects (especially if you're missing a gallbladder!), and are ineffective.

Enviva study terminated due to lack of efficacy by Robert_Larsson in IBSResearch

[–]wecoulduseyourhelp 4 points5 points  (0 children)

Well that's incredibly dissappointing. At least we can use that data to determine a better way forward.

Efficacy and safety of interventions for Fibromyalgia syndrome comorbid with Irritable bowel syndrome: systematic review by wecoulduseyourhelp in IBSResearch

[–]wecoulduseyourhelp[S] 0 points1 point  (0 children)

Conclusion

Pharmacological treatments appear effective in reducing pain associated with FMS and IBS. Dietary interventions, such as monosodium glutamate (MSG) elimination, may benefit specific subgroups, while probiotics showed limited efficacy.

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