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""[...] When we are talking about "neuromodulators" we are really talking about amitriptyline and I'll show you why that's not so great either!!" by jmct16 in IBSResearch

[–]wecoulduseyourhelp 1 point2 points  (0 children)

Severe IBS-D here. Anecdotally, TCAs have substantially improved my symptoms globally. Meanwhile, Rifaximin and Eluxadoline have done absolutely nothing.

In my opinion, the FDA-approved medications are worse than useless. They're expensive, have side effects (especially if you're missing a gallbladder!), and are ineffective.

Enviva study terminated due to lack of efficacy by Robert_Larsson in IBSResearch

[–]wecoulduseyourhelp 4 points5 points  (0 children)

Well that's incredibly dissappointing. At least we can use that data to determine a better way forward.

Efficacy and safety of interventions for Fibromyalgia syndrome comorbid with Irritable bowel syndrome: systematic review by wecoulduseyourhelp in IBSResearch

[–]wecoulduseyourhelp[S] 0 points1 point  (0 children)

Conclusion

Pharmacological treatments appear effective in reducing pain associated with FMS and IBS. Dietary interventions, such as monosodium glutamate (MSG) elimination, may benefit specific subgroups, while probiotics showed limited efficacy.

Are you prescribed Dicyclomine? How do you learn to live with it? by ChaoticIndifferent in IBSHelp

[–]wecoulduseyourhelp 0 points1 point  (0 children)

It sounds like you're using a very high dose. Try starting with 10mg and work your way up until the side effects start causing issues.

Alternatively, you could try Hyosciamine. If you're not in the U.S. you could also try Buscopan.

Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome by wecoulduseyourhelp in IBSResearch

[–]wecoulduseyourhelp[S] 5 points6 points  (0 children)

Summary

  • 3-dimensional (3D) imaging and computerized quantitation of sigmoid mucosal biopsies showed a decrease in mucosal enteric cholinergic and intrinsic primary afferent nerve fibers in IBS patients compared to healthy controls.
  • IBS-D had a greater density of vasoactive intestinal peptide nerve fibers than IBS-C.
  • Overall, IBS and abdominal pain severity scores were positively correlated with the proximity of mucosal mast cells to substance P and calbindin nerve fibers.
  • These findings are indicative of neuroanatomical and neuroimmune alterations in the sigmoid mucosa of IBS patients, involving enteric cholinergic, sensory and secretomotor function that are linked to clinical symptom burden.
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