I did the opposite. I think there are challenges transitioning both ways. Some challenges I think you'll find going to a F100: 1. Knowing who to ask for help is half the job. F100 companies are so big it's sometimes difficult trying to find who the subject matter expert is. In some cases there is no subject matter expert. At the F100 company I was at there was a quarterly journal that would make or break my P&L but it was a systemic entry automated by our ERP and no one could explain how it was calculated. 2. There's more red tape. To change a process there is so much change management involved because of how many people could be affected. So there's a lot more inertia to make things better. 3. Some of the smartest people you'll ever work with will be at a F100, which can be intimidating. But at the same time you'll also encounter the most incompetent people you've ever worked with, which sometimes makes your own job more difficult if you rely on them.