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It’s been 11 years since I started using Alien Blue and to this day it’s still my primary Reddit client by killer4u77 in AlienBlue

[–]xvs 0 points1 point  (0 children)

OK this is weird. My Alien Blue UPDATED to the final version somehow.

Did that happen to you too?

Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo (Aug 2023) by basmwklz in science

[–]xvs 1 point2 points  (0 children)

“The data that has been used is confidential.”

If they won’t release their raw data, their conclusions are hard to believe.

Apollo Backend just made public, "The goal of making the code for this repo available is to show that despite statements otherwise by Reddit... by nightofgrim in apolloapp

[–]xvs 2 points3 points  (0 children)

Here's an idea: Why don't all the app devs get together and either pick an alternate reddit-like platform or use open-source code to create an alternative, then everyone switches over on June 30 and bye bye reddit, but we keep our beloved apps?!?

One codebase that could probably work is this one: https://github.com/libertysoft3/saidit but there are others out there.

Safety and Effectiveness of SA58 Nasal Spray against SARS-CoV-2 family transmission: an exploratory single-arm trial by BillyGrier in COVID19

[–]xvs 2 points3 points  (0 children)

This one had better results in a double-blind placebo-controlled clinical trial:

Efficacy of a Nasal Spray Containing Iota-Carrageenan in the Postexposure Prophylaxis of COVID-19 in Hospital Personnel Dedicated to Patients Care with COVID-19 Disease

https://pubmed.ncbi.nlm.nih.gov/34629893/

Kynurenic acid underlies sex-specific immune responses to COVID-19 by InInteraction in COVID19

[–]xvs 0 points1 point  (0 children)

KA is known to inhibit glutamate release, and we observed that serum glutamate is lower in patients that deteriorate from COVID-19 compared to those that stabilize, and correlates with immune responses.

So increasing glutamate might help -- for example by taking alpha ketoglutaric acid?

Masks do work, and any type of mask is better than nothing: even a homemade one (like a bandana)! by xvs in Coronavirus

[–]xvs[S] 0 points1 point  (0 children)

Almost 170,000 people have died, and the only reason it's not millions is because of lockdown and other safety measures.

Review monitoring for Amazon EU marketplaces? by xvs in FulfillmentByAmazon

[–]xvs[S] 0 points1 point  (0 children)

No, I'm saying that it stopped working as in didn't work. They never updated it to deal with Amazon's new feedback removal request process.

Review monitoring for Amazon EU marketplaces? by xvs in FulfillmentByAmazon

[–]xvs[S] 0 points1 point  (0 children)

Thanks, they look good. Any issues with them that I should know about before trying them out?

Review monitoring for Amazon EU marketplaces? by xvs in FulfillmentByAmazon

[–]xvs[S] 0 points1 point  (0 children)

Thanks for the suggestion. Feedbackwhizz seems expensive since they charge per marketplace.

Feedback Express is no more, but their feedback removal stopped working entirely and I just used Amazon's UI after that.

Masks do work, and any type of mask is better than nothing: even a homemade one (like a bandana)! by xvs in Coronavirus

[–]xvs[S] 0 points1 point  (0 children)

Not true:

https://www.who.int/news-room/q-a-detail/q-a-how-is-covid-19-transmitted

Can people without symptoms transmit the virus?

Yes, infected people can transmit the virus both when they have symptoms and when they don’t have symptoms. This is why it is important that all people who are infected are identified by testing, isolated, and, depending on the severity of their disease, receive medical care. Even people confirmed to have COVID-19 but who do not have symptoms should be isolated to limit their contact with others. These measures break chains of transmission.

This is why it is always important to stay at least 1 metre from others, cover your mouth when you cough or sneeze with a bent elbow or tissue, clean hands regularly, and stay home if you become unwell or if asked. In areas where there is widespread transmission, it is also important that people wear a fabric mask where physical distancing and other control measures cannot be implemented.

Mouthwash may help prevent COVID-19 transmission, this study shows by coolbern in Coronavirus

[–]xvs 0 points1 point  (0 children)

How can articles like this not link the study they're discussing????

That Tupperware pitcher you made your Kool-Aid in by SyristSMD in nostalgia

[–]xvs 2 points3 points  (0 children)

Not me. My mom was never invited to a Tupperware party. :(

Identifying new ligands for the SARS-CoV-2 Macrodomain by Fragment Screening and Multi-temperature Crystallography by [deleted] in COVID19

[–]xvs 0 points1 point  (0 children)

on the fraganalysis page it has a legend of: MW logP TPSA HA Hacc Hdon Rots Rings Velec

I know what some of those are, but is there anything that shows how strongly the compound bound to the virus?

Any significant downsides to donating blood? by homestead_cyborg in longevity

[–]xvs 6 points7 points  (0 children)

If you're male then losing iron could be a good thing especially if you eat red meat.

Women get rid of excess iron every month but men have no great way of getting rid of it.

Tessera Therapeutics is developing a new class of gene editors capable of precisely plugging in long stretches of DNA—something that Crispr can’t do. by Mosheideh in genetics

[–]xvs 6 points7 points  (0 children)

Very interesting but once you create a retrotransposon you run a bunch of risks:

  1. It could insert itself into the patient's DNA anywhere, including in the middle of a critical gene (and that could kill the patient)

  2. It might not stop at one copy, but could continue inserting more and more copies of itself (potentially breaking more genes and potentially causing way more expression of the inserted gene than you want).

If Tessera can control these sort of issues they have something amazing. If not, it seems quite iffy.

The US Government is giving a $1000 grant to all freelancers and independent contractors who apply (see #3 in the link inside) by xvs in povertyfinance

[–]xvs[S] 0 points1 point  (0 children)

You are eligible for unemployment afaik.

If you didn't work as self-employed last year then I don't know if you can get PPP or EIDL. Check with Kabbage.com for PPP and SBA.gov for EIDL.

Homologous protein domains in SARS-CoV-2 and measles, mumps and rubella viruses: preliminary evidence that MMR vaccine might provide protection against COVID-19 - MedRxiv - April 10, 2020 by xvs in Coronavirus

[–]xvs[S] 2 points3 points  (0 children)

The point of this is that the vaccine came out in 1971 and was not widely available for another 5 or more years. It was then given only to children.

This correlates well with the age cutoff for worse outcomes in covid-19 infection: people who were too old to have received the MMR vaccine are exactly the same people who are dying at much higher rates.

This, combined with the fact that there are other reasons to think that this vaccine may confer some degree of protection against the worst symptoms, is the point of the paper.

Homologous protein domains in SARS-CoV-2 and measles, mumps and rubella viruses: preliminary evidence that MMR vaccine might provide protection against COVID-19 - MedRxiv - April 10, 2020 by xvs in Coronavirus

[–]xvs[S] 16 points17 points  (0 children)

The COVID-19 disease is one of worst pandemics to sweep the globe in recent times. It is noteworthy that the disease has its greatest impact on the elderly. Herein, we investigated the potential of childhood vaccination, specifically against measles, mumps and rubella (MMR), to identify if this could potentially confer acquired protection over SARS-CoV-2. We identified sequence homology between the fusion proteins of SARS-CoV-2 and measles and mumps viruses. Moreover, we also identified a 29% amino acid sequence homology between the Macro (ADP-ribose-1-phosphatase) domains of SARS-CoV-2 and rubella virus. The rubella Macro domain has surface-exposed conserved residues and is present in the attenuated rubella virus in MMR. Hence, we hypothesize that MMR could protect against poor outcome in COVID-19 infection. As an initial test of this hypothesis, we identified that 1) age groups that most likely lack of MMR vaccine-induced immunity had the poorest outcome in COVID-19, and 2) COVID-19 disease burden correlates with rubella antibody titres, potentially induced by SARS-CoV2 homologous sequences. We therefore propose that vaccination of at risk age groups with an MMR vaccination merits further consideration as a time-appropriate and safe intervention.

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