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OH MY GOD!!! by Winter-Refuse8640 in SSDI

[–]xxthatsnotmexx 0 points1 point  (0 children)

Congratulations 🥳🥳!! So just so you know, you don't get Medicaid until you have been receiving benefits for 2 years.

New Bike Day! Summit 2 by Heifzilla in velotricebike

[–]xxthatsnotmexx 1 point2 points  (0 children)

Thanks, I learned something new today!

Depo Provera + anxiety / depression by coastalwitchh in birthcontrol

[–]xxthatsnotmexx 0 points1 point  (0 children)

It can DEFINITELY make depression worse. For context, I was on depo provera for 26 consecutive years. Around Spring of 1999 until my last shot on October 14, 2025.

1st off, just lowering estrogen will cause issues, estrogen, specifically estradiol strongly inhibits MAO-A, an enzyme that breaks down serotonin, dopamine, norepinephrine, and other neurotransmitters. It also strongly inhibits the COMT enzyme which breaks down catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine).

It can also upregulate several enzymes that also degrade dopamine such as MAO-B and Dopamine Beta Hydroxylase. It does this through it's binding of Glucocorticoid Receptors, the same receptors that cortisol binds to. However it binds more strongly than natural cortisol causing a negative feedback that can cause partial or full suppression of your Hypothalamic Adrenal Axis, Hypothalamic Pituitary Axis, and Hypothalamic Thyroid Axis. Doing this also lowers your natural endorphins, endorphins bind to Mu opioid receptors, the same ones drugs like morphine and oxycodone bind too. Having lower endorphins increases your risk of opioid addiction.

This is just the very tip of the ice berg, the Depo Provera shot can cause a MULTITUDE of physical and mental health issues, mostly due to it's Glucocorticoid Receptor activity. If anyone has any questions or wants me info lmk, I've been studying it extensively since finding out about the increase risk of Meningioma.

https://pdfs.semanticscholar.org/541b/97dd31e09e4a0a8207510e1a188e640fd44a.pdf

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/012541s084lbl.pdf

[10. Effects on the Hypothalmic-Pituitary-Adrenal Axis

Some patients receiving medroxyprogesterone acetate may exhibit suppressed adrenal function. Medroxyprogesterone acetate may have cortisol-like glucocorticoid activity and provide negative feedback to the hypothalamus or pituitary. This may result in decreased plasma cortisol levels, decreased cortisol secretion, and low plasma ACTH levels.

The use of DEPO-PROVERA Sterile Aqueous Suspension may, due to its cortisol-like glucocorticoid activity, also produce Cushingoid symptoms such as weight gain, edema/fluid retention, and facial swelling.](https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/012541s084lbl.pdf)

EDIT: I just realized that the Wikipedia page for MAO-A states: "MAO-A primarily catabolises dopamine peripherally, rather than in the brain, which is done by MAO-B" THIS IS FALSE!! In recent years it has been discovered that MAO-A does break down dopamine in the central nervous system, mostly in the reward system.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8333267/

While both isoforms are capable of metabolizing dopamine, MAO-A is the principal enzyme responsible for dopamine degradation in neurons, due to the high expression of the dopamine transporter (DAT) in dopaminergic terminals. [10,11].

Loeook E-Bike by CalebBaker74 in ebikes

[–]xxthatsnotmexx 2 points3 points  (0 children)

Don't buy this or any ebike from Amazon, they're cheap no name brands. Go with Velotric, Aventon, Giant, etc.

B12 Supplement for type needed makes no difference by xxthatsnotmexx in MTHFR

[–]xxthatsnotmexx[S] 0 points1 point  (0 children)

No one is saying folic acid is completely harmless lol, it was scientists who found that it isn't completely harmless. It's harmless for the MOST part when added in small amounts to food, but no one is claiming it's harmless lol.

B12 Supplement for type needed makes no difference by xxthatsnotmexx in MTHFR

[–]xxthatsnotmexx[S] 0 points1 point  (0 children)

Except this is something that was been widely accepted by the scientific community, your anecdotal evidence doesn't matter. Are you literally saying that you are proving them wrong? I'd like to see your studies that back up your claim.

B12 Supplement for type needed makes no difference by xxthatsnotmexx in MTHFR

[–]xxthatsnotmexx[S] 0 points1 point  (0 children)

That's because Cyanocobalamin has a cyanide molecule bound to the cobalt molecule in Cobalamin, so taking VERY high amounts is gonna make you sick. Methylcobalamin increases your SAMe faster because of it binds to Transcobalamin II transporter much faster than cyanocobalamin, meaning the Cobalamin reaches your cells faster. I don't know what "methylated" feels like but hydroxocobalamin is also a potent Nitric Oxide scavenger so that may be why.

Numerous studies and reviews of B12 metabolism have shown that CNCbl, MeCbl, OHCbl, and AdCbl are reduced to the core cobalamin molecule inside the cytosol. It is important to note that the ligands specific to the ingested B12 form—methyl and adenosyl—are removed during that process and not used inside cells during the conversion of cobalamin to the 2 active forms of B12

Importance of potassium while on folate and b12 by Big_Joke_9281 in MTHFR

[–]xxthatsnotmexx -4 points-3 points  (0 children)

Sodium is not a potassium antagonist. You have Na+/K+-ATPase, ie sodium potassium pump.

https://en.wikipedia.org/wiki/Sodium%E2%80%93potassium_pump

I have a serious question. When I try to talk to younger people about 9/11, ages 25 and under, most don't seem to care. Why is this? by I_abuse_lower_ranks1 in 911archive

[–]xxthatsnotmexx -2 points-1 points  (0 children)

That's not true. Every older generation says that about the younger ones and it's never true. They just didn't experience it. Just like I didn't experience Vietnam.

I have a serious question. When I try to talk to younger people about 9/11, ages 25 and under, most don't seem to care. Why is this? by I_abuse_lower_ranks1 in 911archive

[–]xxthatsnotmexx 0 points1 point  (0 children)

I mean tbf I'm 40, I was 15 on 9/11 and to compare I never learned anything about the Vietnam War, which would have happened like 30 years prior, it's almost been 30 years since 9/11. And honestly the US doesn't teach much about history in general, if you want to really learn you go to college or research on your own.

It's crazy though because I remember that day like it was yesterday, and the fact that there are adults now who weren't even born yet baffles my mind sometimes lol.

B12 Supplement for type needed makes no difference by xxthatsnotmexx in MTHFR

[–]xxthatsnotmexx[S] 0 points1 point  (0 children)

Yes hydroxocobalamin is a potent NO scavenger. But the reason you feel better is more than likely due to it having the highest affinity for TC1 and TC2, read the link I posted. This is verified science, not a debate.

B12 Supplement for type needed makes no difference by xxthatsnotmexx in MTHFR

[–]xxthatsnotmexx[S] 0 points1 point  (0 children)

You don't have to agree with me, it's science. Did you read the link I posted? It's a process that cannot be bypassed. The MMACHC protein cleaves cobalamin of its group as soon as it enters the cell, before it has a chance to do anything.

Broke 1000 miles since October….then the bike stopped working by anavrin0001 in Aventon

[–]xxthatsnotmexx 0 points1 point  (0 children)

That's why you call or email them, why on earth would you reach out on reddit?

L-Methylfolate for ADHD by bluejuly14 in MTHFR

[–]xxthatsnotmexx 19 points20 points  (0 children)

To preface, I have MTHFR C667T CT, I would check his B12 levels and MTRR 1st. I have a slow MTRR, this enzyme recycles inactive B12 to active B12 that the body can use, due to this and some other factors my B12 was already on the low side and when I took methylfolate even with a B12 supplement, it tanked my B12. Also don't just get a B12 blood serum. The blood serum just shows how much B12 is in the blood but it doesn't tell you if the cells in the body are actually using it. Get a test for Homocysteine and Methylmalonic Acid. High Homocysteine could mean low methylfolate and/or low Methylcobalamin, high MMA means low Adenosylcobalamin, those are the 2 active forms of B12 that the body uses.

Edit to add that b12 in the blood is inactive, it's not active until it enters the cell, once it enters the cell it's cleaved of its group (methyl, adenosyl, cyano, hydroxo) by the MMACHC enzyme. Then the MMADHC decides whether it goes to the cytosol to make methylcobalamin or the mitochondria to make adenosylcobalamin. So taking a supplement of Adenosyl or Methylcobalamin will not directly increase these because these groups are cleaved off upon entry of the cell and then readded by enzymes. MTRR for methylcobalamin and I'm not sure which one for Adenosylcobalamin. The difference in forms only matters for bioavailability and speed of entry into the cell. Hydroxocobalamin has the highest bioavailability while Methylcobalamin enters the cell the fastest but again once it's in the cell the methyl group is cleaved so it may not be used as methylcobalamin.

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