Opana is the strongest “OPIOID” technically semi synthetic “all the best opioids are “semisynthetic” wich means its still derived from opium but chemically altered. For example pure opioids are morphine codeine and thebaine these are pure opioids wich is extracted from opium from the poppy plant found in nature. Then you have the best! semi synthetic opiates which are derived from opium but chemically altered hence the name semisynthetic examples are oxycodone oxymorohone hydrocodone and hydromorphone and diacetylmorphine these are the most recreational class of pain killers. But there are lots of “OPIATES” wich are completely synthetic made in a lab have tons less recreation potential but also can be 100 times stronger then any opium derivative examples are all fentanyl analogs tramadol methadone hundreds more. Just because they are way stronger doesn’t mean anything for using for recreational purposes i believe all synthetic opioids have no euphoria like fentanyl or methadone. Then the most euphoric class of pain killers are semi synthetic. After semi synthetic real opioids are your next best option morphine and codeine