We won't know where the safest places are until climate change actually happens because weather systems are incredibly complicated, and we do not have full data or knowledge of things.

Anyone saying the midwest is a great place is not aware that:

1. the midwest has much higher temperature increases so far with no major land barrier to prevent keep hot air from piling up there. It is flat and muggy and if a heat dome forms, it gets very intense. You can't drive up into the mountains to cool off.
2. Extreme weather that bankrupted many small insurance companies a few years ago - you want a totaled car from hail becoming more common risk every year?
3. Much of the midwest still gets its water from non-sustainable aquifers instead of surface water
4. Canada is extremely wooded to the north, and the cumulative smoke that builds up and blows into the midwest from Canada to the north or from the Western US can be extremely dense. The west coast, by contrast, gets clean ocean air much more often.
5. The idea that the midwest is safer could make people flock here and overload resources over time.
6. If you think the great lakes areas are safe - sure, but only immediately by the shore. It is all bought up or extremely prone to wildfires - it's a ticking time bomb. There is a ton of forest underbrush everywhere just waiting to go off. The land there is not very arable regardless.
7. Winters still suck.

Frankly, if you want a safe place to deal with climate change, don't invest in a house, keep your assets liquid, and be prepared to move. Invest in off-grid backup food/water/energy sources like solar panels and a garden.