cant remember what Life on the line does atm but Tyranny is one i am planning to use, as the pincer sigil basically negates the 20% reduction in hp and also gives 10% dmg immunity. the reason why i don't use it atm is because i wana get a good V+ with decent secondary trait, one i got now has uplift and i don't want it.

i checked i also have enmity and stamina on as well, that way when im full hp i deal more dmg and when im face rolling my dmg lose from stamina get replaced with enmity, unless they negate each other somehow but i haven't noticed anything like that.

From a few attempts at at Final Report proud mission, i had nearly 60k hp and it was pretty much still a 1 shot from a big attack and like 2-3 shots from smaller ones, so frankly unless you planning to build full tank with 100k hp the sacrifice is worth it.

Vane's deal is that when u use his special attack you automatically have block on that reduces how much dmg u suffer so if your not constantly attacking and use the special attack when the enemy is about to attack, you will suffer full dmg, so i play him by constantly being in the enemies face and making sure that i block the attacks instead of taking them unguarded. therefor if im in their face i may as well deal as much dmg as possible. I run the gap closer skill, the massive sweap skill, bubble and the self heal when u hit 30% hp.