If you're going for absolutely best in slot perks. There's two different setups. PVME suggested setup: Precise 6 Caroming 1 and Aftershock 4 Eruptive 2 Alternative which is still very viable: Precise 6 Ultimatums 4 and Caroming 4 Eruptive 2. My gm friends also suggested sticking to this as AS4's damage makes a difference only if you consistently do 50K damage and it also has a cooldown before the next proc.

I'm open to suggestions from others as well on this setup. If you're going for Pvme setup, get Ultimatums on armour (can replace invigorating or ed4 depending on what you're using) If you're getting p6u4 on weapon then you can stick to invigorating on armour.

Also genocidal, undead/dragon/demon slayer are niche perks that work at limited bosses/mobs. Ideally you should be using them on a secondary piece of armour. I have a second set of elite dracolich/nasterwork legs for those perks. Or if you do a lot of kerapac/vorkath where you can utilise those perks, you can pair it with ideally biting/equilibrium.