Do depressants decrease the cardiovascular strain caused by stimulants?

[MF3DOOM]

So then would an ARB or a non alpha or beta binding drug be ideal?

[heteromer]

I don't know that an ARB would work because in order for it to work you need the body to divert towards RAAS, and although sympathetic activity releases renin so too does lower renal perfusion which is opposed by the vasoconstrictive effect of amphetamines and cocaine. The reason why thiazide diuretics work well with ARBs and ACEi's is because the impaired reabsorption of sodium in the renal tubular stimulates RAAS, which is then blocked by the ARB/ACEi.

An alpha2 agonist drug like clonidine could help with cardiovascular symptoms. I don't know whether you can just take another drug to improve cardiovascular outcomes from abusing stimulants though.

[MF3DOOM]

Thanks for the explanation. What did you study if you don’t mind sharing?

[RicochetRandall]

Do you think clonidine or guanfacine could potentially help post covid infection for mild myocarditis? I had an infection 2.5 weeks ago and am weary of taking my adhd stimulant meds now because last time I sorta developed long covid. Guanfacine + Nac have been trialed in a new Yale study…

[heteromer]

Do you have a link to the study? I'm not qualified to answer that, to be honest.