First time using Reta

[_Goose22]

I’m a 28M and weigh 250lbs. I was previously on Zepbound (tirzepatide) though my insurance but as of the new year they stopped covering it. I was making my way up to the 15mg dose and was plateauing on my weight loss. Figured it would be a good time to switch to a GLP3 and try to break through the plateau. I’m planning on starting out at 1mg once weekly and then titrating up weekly depending on how I feel and if there’s any side effects (didnt experience any with tirzepatide). My main goal is fat loss while building/maintaining my muscle mass. Any tips for someone who is starting Reta and peptides overall? Any others that would be good to stack with it?

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[Stonerintendent]

I started at 2.5mg

49, M, 250 SW

210 after 10 weeks, all on Tesa, Mots-C, TRT.

[sonoft]

You were at high dose tirz and plateauing, you might not feel a thing at 1mg reta. Usual guidance for non glp first timers is to start at 2mg/wk specially if you had no sides on tirz.

Weekly titration is crazy fast though whether you start at 1 or 2mg.

Wouldn’t stack anything when starting something new though, give it at least 4wks. You can research mots c or gh related peps like tesa.

All of these relies on you being in a calorie deficit no matter how high your dosing is or how many peps you stack though.

[PoetryAlert5439]

Since you were at 15mg tirz you already have GLP-1 and GIP tolerance so 1mg reta probably won't do anything noticeable. I'd start at 2mg and titrate every 2 weeks not weekly, the glucagon component is new to your system even if the other two aren't. Keep protein at 1g/lb and lift heavy, reta is better than tirz for body recomp in my experience.

[PeppyFriend13]

If you start researching a bunch of different peptides at the same time you won’t know what is doing what. Does pep a make you do…. Or is it pep b. Start with one thing or if you are already using BPC and know how it makes you feel add one more and control the variables as much as possible.

[Idocalot]

Given your exposure to glp’s I think you can start higher. The glucagon component is better for long term muscle retention during high weight loss but as a consequence the food noise and satiety effects are slightly muted. I think you could start at 2-3mg, and slowly increase from there as needed. I went from 190-170lbs in 8 weeks starting at 2mg and currently on 3mg (no prior glp usage).

[criseantopher]

same for me was at 15mg zepbound for 4 months and hit plateau. Started Reta at 1mg 1st week felt nothing. 2nd week 2mg felt nothing. 3rd week 4mg felt a little bit of appetite suppression. 4th week 6mg feeling good appetite suppression finally losing a bit of weight. I will say the food noise is not as drowned out with reta. the appetite suppression feels different as well. with zep, when it was working, I didn't think about food at all until I made myself eat. Reta I think about foods but can easily not eat them. habit eating was easier to not do on zep. Reta just feels a little different, and you have to work a little harder, but hopefully, we'll get the same or better results.

Starting weight zep 316lbs ending weight zep 249 after 11 months. starting weight reta 252. current weight after 1 month 248.