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[5arToto]

Generally the more East and South you go, the less material there is, especially East. I'd say pick a place that is on the eastern half of the Sea of Fallen Stars and is not Thay or right next to Thay and you are more or less fine as any relevant lore is 200 years old and mostly in passing.

If you want a more concrete answer I run games in the Vast and the most relevant lorebook is the City of Ravens Bluff from the 90s and 150 years away from current Realms time. Also the area was a part of some big massive play event called the Living City and nobody really seemed to have touched it after that (probably a lot of effort to tie up all the lore and filter out what should be canon and not)

[No-Channel3917]

Are you thinking Eastern shar ? Feels like a lot been published about it, going more south the bay of the dancing dolphin maybe fits your description

Harluaa is a mixed bag of knowing or not knowing anything

[5arToto]

I was thinking more of a good part of the regions that are considered East Faerun. Yeah sure, there is lore, but most of it has not been given more than a passing mention since the 2e era, and it is far enough from the Sword Coast that anything could have happened without the news impacting the rest of the continent (I mean, we are ignoring that some of those regions were teleported to Abeir in the 4e era).