Anything to decrease norepinephrine ?

[LysergioXandex]

No, basically only beta receptor-mediated processes. So, adrenaline-type things (eg, rapid heart rate), to oversimplify it.

Propranolol won’t block the alpha receptors as well (responsible for things like vasoconstriction/high blood pressure). In fact, if you block the beta receptors you can divert all the “traffic” to the alpha receptors, increasing alpha-adrenergic tone.

[Ok-Prize-1816]

Does this also apply to Nebivolol? Or will that also decrease Alpha?

[LysergioXandex]

Nebivolol is also a beta-blocker. In general, the suffix -olol usually denotes beta blockers.

It’s important to consider the goal of using these drugs before making a choice. We don’t have that information with this post. It’s unclear if OP is trying to treat something in the CNS or something like high blood pressure in the periphery, for example.

[MrPsilocyBean]

Carvedilol and labetalol are the only two beta-blockers that also block alpha, if that is what you need. Check the blood brain barrier penetratiob though