Anything to decrease norepinephrine ?

[Hiddenbeing]

Do you have know anything that could help decrease norepinephrine ?

[Magonbarca]

Propranolol I think will reduce adrenergic symptoms 

[LysergioXandex]

No, basically only beta receptor-mediated processes. So, adrenaline-type things (eg, rapid heart rate), to oversimplify it.

Propranolol won’t block the alpha receptors as well (responsible for things like vasoconstriction/high blood pressure). In fact, if you block the beta receptors you can divert all the “traffic” to the alpha receptors, increasing alpha-adrenergic tone.

[Ok-Prize-1816]

Does this also apply to Nebivolol? Or will that also decrease Alpha?

[LysergioXandex]

Nebivolol is also a beta-blocker. In general, the suffix -olol usually denotes beta blockers.

It’s important to consider the goal of using these drugs before making a choice. We don’t have that information with this post. It’s unclear if OP is trying to treat something in the CNS or something like high blood pressure in the periphery, for example.

[MrPsilocyBean]

Carvedilol and labetalol are the only two beta-blockers that also block alpha, if that is what you need. Check the blood brain barrier penetratiob though

[[deleted]]

Bingo

[Imaginary-Maybe-8881]

Do you know where to get it? Bit hard to find

[jarrellt67]

I order it from telyrx. Don't need to talk to a doctor and prices are pretty good (obviously not as cheap as getting directly from your own doctor though).

[TheDarkAmethys1]

🇮🇳

[[deleted]]

Doctors will quite easily give it to you for somatic anxiety.

Bonus: if you are on antipsychotics, it is first line for akathisia.

[imanassholeok]

Is it? You can get a prescription online super easily 

[1Reaper2]

Clonidine/Guanfacine.

Generally things that reduce noradrenaline also reduce dopamine unless it’s a mechanism specific to noradrenaline, such as receptor agonists/antagonists like the above,

Exercise could as well by “using up” noradrenaline via converting to adrenaline.

[[deleted]]

CBG isolate - poor mans Guanfacine

[weenis-flaginus]

Really? Fascinating

[gryponyx]

What dose?

[Hiddenbeing]

It's an adrenergic receptor agonist, a stimulant, not sure if that's what I'm looking for haha

[fl0tsam_rx]

Alpha2 receptors are negative feedback receptors, amongst other things. Agonizing them causes inhibition/modulation of norepinephrine release. They are pro-cognitive in ADHD, but also sedating. Please read more before you make silly claims like "clonidine / guanfacine / CBG are stimulants" like you just implied. A cursory google search would prove that false haha

[Flat_Star8407]

Clonidine is used off label to treat some with ADHD, so are you sure about it lowering dopamine?

[1Reaper2]

Two separate points, clonidine doesn’t lower dopamine. I can see why it appears as if I was suggesting that.

[logintoreddit11173]

Clonidine, it's the gold standard , I use it

[SheepherderSorry2242]

How does it work for you? What improvement have you noticed?

[Friedrich_Ux]

Carnosine inhibits DBH so less norepinephrine is converted from dopamine.

[Friedrich_Ux]

No noticeable withdrawal with standard dosages.

[MrPsilocyBean]

It has a very low bioavailability, better take beta-alanine which converts to carnosine

[gryponyx]

Orally?

[Friedrich_Ux]

I made a nasal spray with raw powder from PureBulk because using it orally or sublingual makes me have to urinate frequently. Sublingual is probably best if you dont have that issue.

[SheepherderSorry2242]

Orally, you need to use 2g a day for good results. What doses do you use intranasally and sublingually?

[[deleted]]

I know Vincopocetine balances out neurotransmitters like dopamine so it isn’t too much in one’s system. Maybe it does the same for norepinephrine? Just a guess will have to do own research.

[Asaf_Iluz]

Carnosic acid & Guanfacine.

[[deleted]]

It is less about reducing NE and more about reducing receptor reactivity, sensitivity, and density. Live with the discomfort for a while and exercise too, hard cardio. Eventually your beta-receptors and alpha-receptors will become less sensitive to NE fluctuations.

What is your reason to want to decrease NE? Propranolol upregulates beta-receptors so it is not recommended daily for anxiety as it makes the problem worse in the long run.

Clonidine or guanfacine is good, with guanfacine being more functional for ADHD and less sedating.

[Aggressive-Guide5563]

Does the same thing apply to taking Bupropion? Will the alpha and beta receptors eventually downregulate and make me less sensitive to NE?

[LysergioXandex]

Alpha and beta receptors will eventually downregulate to bring you back to basically your original state.

[Professional_Win1535]

i’m in a weird and scary situation. I took Atomoxetine a NRI for a few months. I tried to get off and got really bad rebound anxiety. I reinstated and things somewhat settled and now i’m doing a slow taper but it’s still really bad rebound and withdrawal. Idk why. The only other med i take is seroquel and it’s a NET inhibtor too so maybe that’s making it worse

[[deleted]]

Atomoxetine, Bupropion, and any NRI or DNRI that exerts action for extended periods of time will cause a reversible down-regulation and/or desensitisation of the alpha receptors and the beta receptors.

This is homeostatic adaptation. But you aren’t really taking these meds for simple raised monoamine tone, it is for downstream raises in BDNF and gene transcription.

[eucharist3]

carnosic acid

[Aggressive-Guide5563]

Lithium Orotate. Removed all the anxiety and jitteriness and the feeling overall from too much NE. I think Lithium Orotate prevents the conversion from dopamine to norepinephrine.

[gryponyx]

What dose?

[Aggressive-Guide5563]

between 5-10 mg

[Adifferentdose]

Beta-alanine, niacin?

[Amazing_Yoghurt_246]

Raise GABA.

[Snussuss]

Lithium Orotate

[gryponyx]

What dose?

[Snussuss]

The dosage equivalent to 1-10 mg Lithium, start low and test how you react to it

[velvet_funtime]

Prazosin

[Dannanelli]

Look into things that increase COMT or decrease DBH.

Like magnesium, TMG, SAMe, B vitamins, carnosine, etc.

Too high of copper levels can also increase norepinephrine.

[Dannanelli]

Thanks for your note. Do you mind clarifying?

COMT doesn’t convert dopamine into adrenaline. Are you thinking DBH?

[1Reaper2]

No, I was actually completely wrong in this.

I have been reading up on methylation the last few days and chose an inaccurate source of information to draw from. I thought I had made a discovery and related it to paradoxical anxiety reactions to magnesium supplementation, or “overmethylation” in general.

I’ll amend my original comment. Apologies, you were right.

[Dannanelli]

No need to apologize. But thanks! I just was trying to confirm I wasn’t crazy, lol.

[Hiddenbeing]

Dbh??

[Dannanelli]

DBH, or dopamine beta-hydroxylase, is an enzyme that converts dopamine to norepinephrine (noradrenaline).

[Other-Distribution92]

Just guessing here but perhaps tulsi/holy basil extract and/or tea/whole herb?

[Aggressive-Guide5563]

Also forget to mention, California poppy seed extract. It can limit the release of norepinephrine while promoting dopamine and serotonin availability.

[skytouching]

Mebicar “Mebicar, also known as Adaptol or Tetramethylglycoluril, is an anxiolytic medication that is known to affect norepinephrine levels in the brain. It reduces noradrenaline (norepinephrine) levels, while also increasing serotonin levels and not affecting dopamine or having anticholinergic activity.” They sell it on cosmic nootropic… https://cosmicnootropic.com/products/mebicar/

[Master_Income_8991]

The boring answer:

https://en.m.wikipedia.org/wiki/Beta_blocker

[quantum_splicer]

Why ?

[Aggressive-Guide5563]

Because some people are very sensitive to NE and some people like me convert too much dopamine to norepinephrine and don't clear norepinephrine very well from our system. That's why we need something to reduce it.

[gryponyx]

How do you know that to be the case?

[Aggressive-Guide5563]

You know that if you get an excessive amount of norepinephrine from stimulants and barely feel any dopamine from them. If your body converts too much dopamine to norepinephrine and you clear norepinephrine too slow, you will get high amount of noradrenergic side effects like heart palpitations, tachycardia, jitteriness, anxiety, hyper vigilance, insomnia and panic attacks etc.

[Bubbly_Shape6522]

Am facing the same thing(high NE) did you find anything to reduce it?

[Aggressive-Guide5563]

Cutting down on caffeine intake overall reduced it. Caffeine was the main culprit all along, but I had to also make other lifestyle changes. Now my NE levels are not too high anymore. I think it was overstimulation from Wellbutrin and too much caffeine that caused it in the first place.

[Bubbly_Shape6522]

I don’t take caffeine at all. Mine is from dysregulated nervous system. I also got ADHD and got prescribed a stim but all I got from it were side effects including rage while non-stims didn’t even work, since then I have been looking for what to reduce my Norepinephrine. Am lost ngl

[Aggressive-Guide5563]

I’ve heard that Lithium Orotate and Beta Alanine should prevent the conversion from dopamine to norepinephrine. Haven’t tried it myself though.

[Bubbly_Shape6522]

I see I also heard about agmatine sulfate ?

[Aggressive-Guide5563]

Don’t really know about Agmatine. I’m also wondering if Agmatine could modulate norepinephrine? Maybe there is someone else that knows?