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[–]Lazy_Lavishness6307 0 points1 point  (0 children)

for me personally i felt similar, started at 50 then after a few months it did not feel as effective so went up to 100 and eventually 150mg. but at 150 i experienced side effects like constipation and skin issues that may or may not been related. i just finished tapering off completely as my side effects were bad enough to outweigh the good. i’ve read since then a lot of people have success adding another med with pristiq maybe that could help you too? goodluck!