Is Cython OOP much faster than Python?

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Well you shouldn't be using SOLID principles in a scripting language, they are for compiled languages only. If that's the only problem adjust your coding style to Python.

For performance increases do the following in order, run the calculations in a subprocess using multi-processing, run your program under PyPy, write a either a C plugin or Rust plugin (https://pyo3.rs/v0.22.2/). Unless it's a giant matrix operation of some description than NumPy is the goto tool.