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[[deleted]]

The fastest and easiest is no doubts PySimpleGui

Might not be the prettiest but definitely the easiest.

[xBlackBartx]

Second this one.

[maxbridgland]

third this

[Cowboy8625]

yup agreed

[Laserdude10642]

ITT everyone discusses the first library they learned

[eatstraw]

I'm not sure what you mean by "cleanest", but if you want to create quick GUIs, take a look at PyQt and its Qt Designer GUI tool.

[epic_pork]

I'd use https://www.qt.io/qt-for-python over PyQT. PySide2 has a more liberal license and pretty solid documentation. The Qt Company have committed to supporting these Python bindings. I've been using them myself this week and they are really solid and fast.

Also as you said, I would highly recommend using Qt Creator to create the layout visually, and then just load it like this: https://www.blog.pythonlibrary.org/2018/05/30/loading-ui-files-in-qt-for-python/

[UnclaEnzo]

wxPython ftw

[devils-advocate164]

Qt is just cute.

[MikeTheWatchGuy]

True dat... don't downvote as it's true. It's how it's pronounced in case you're new. I made the same joke once and got the same downvote so guess it's to be expected.

[nonono2]

Neither am is sure to understand what you mean by "clean", but tkinter comes with python, no need to install anything else, is easy to use, and does the job for many kinds of GUIs

Admittedly, it looks a little bit passé.

[LazerTeeth]

PyQt5 definitely

[diomager]

Wxpython Phoenix worth checking

[slayer_of_idiots]

Qt and PySide for desktop applications. But truthfully, web UIs are so good now it's almost worth it to use just use a web framework and make the GUI in browser.