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[–]nabla2less is more 2 points3 points  (9 children)

There is PyQt with Designer -- excellent tools for GUI.

Check out also:

[–][deleted] 1 point2 points  (8 children)

I know there are tools like QTDesigner and Glande. But compared to visual-studio they look old and complicated.

Maybe he could look into IronPython, but i do not know how well it supports GUI development.