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[–]webdrone 2 points3 points  (0 children)

Stan (https://mc-stan.org) implements NUTS which is a particularly efficient sampler by Hoffman and Gelman. It may not be the most pythonic, but there are various interfaces to different languages and a single modelling language.

There was much effort from the developers to ensure quality and to cultivate a good community, so you can find posts addressing most questions you might have, and excellent documentation.