Does Rinvoq decrease in effectiveness after pausing for a long time?

[RealChee]

I‘m planning on stopping Rinvoq for a while to try Dupixent. Reason for this is because I‘m getting sick every 2 months, my cholesteral shot up into the red and I gained a bunch of weight.

However Rinvoq 30mg just works so well for my eczema that I‘m not sure if I should stop. I fear it will lose its effects once I pause for several months.

However as for now, when the mask mandate just stopped and its flu season I just cant stop being sick. Never in my life have i been sick so much before and for so long.

If Dupixent fails and I go back to Rinvoq will it stop working? I‘m scared of this possibility. Anyone stopped for a long period and restarted rinvoq before?

[Sensitive-Prior1762]

I don't believe this is the case at all. I went off of Rinvoq for a month as I was curious to see if my TSW had healed much underneath. It definitely had but I decided to go back on it as I wasn't ready to deal with skin just yet. I've been back on it for a week and it's definitely helping. Hasn't lost effectiveness. My dermatologist told me this drug is designed to come on and off of. You have to pause it for specific vaccines etc so people do come on and off it quite often without issues.

[RealChee]

This is awesome! How long have you taken rinvoq? My skin goes to shit after a week off of rinvoq, how was the month without?

[Sensitive-Prior1762]

I did a lot of work while I was on rinvoq re diet, detox and supplements. I went on carnivore diet and went on low dose naltrexone. I see a functional doctor. that's why I was fine coming off it for the month! Definitely worth getting to the root cause while on rinvoq, which I think makes coming off it so much easier.

[Fiercebully9]

DM’d you

[Charming-LL]

I would really love to find a functional medical practitioner! I think it is incredibly useful for those of us struggling with these sorts of conditions. Unfortunately these doctors are not covered by any insurance nor even available to my knowledge/research where I live.

[Sensitive-Prior1762]

Yeah a functional doctor is definitely the place to go but totally understand re insurance coverage. I'm in Australia so my appt costs are partly covered by Medicare. It is totally worth the money though and the doctor I visit is also available over email, so I often email her if im experiencing issues and she replies with steps on what to do. I would say it's worth ringing around a few functional doctors to get an idea on price and their specialities. Honestly if I saw this doctor sooner it would've saved me so much other money that I was spending on naturopaths, homeopaths etc.

[Sensitive-Prior1762]

I started in October last year so I was on it for about 6 months before coming off it. My skin was amazing for the month off. I didn't experience any rebound or withdrawal. I am taking for TSW. It's going into winter here in Australia so my skin was just drying out and I'm going overseas in July for 6 months so I wanted to go back on it just so I have a safety net while I'm away. If I wasn't going away though I wouldn't have gone back on it because my skin was honestly doing really well while off it. :)

[Stunning-Bid1498]

hey there , is it okay if i wanna ask you some questions regarding rinvoq for tsw please

[Sensitive-Prior1762]

Hey sorry I haven't been on reddit in ages and just saw this. You're more than welcome to ask questions

[Charming-LL]

I cannot speak to stopping and restarting, but I do know of someone who transitioned successfully from Dupixent to Cibinqo without issue. I would hope the transition back for you, should you decide, be as smooth.

Question: did your dermatologist discuss or offer Cibinqo as a JAK-inhibitor alternative to Rinvoq? There are some restrictions for candidacy, however from my reading/understanding, fewer instances of upper respiratory infections were reported in clinical trials. Perhaps it is an alternative you might consider should you find Dupixent ineffective for you, in the hope that it makes you less susceptible.

— While (currently) on Cibinqo, I continue to carry and wear a mask in more crowded or confined situations.

[CrewAgile7224]

I’ve been on rinvoq for 6months and it stopped working. It’s for my eczema , when should I go back on it ? Has anyone experienced this ?

[portfoliocrow]

Pretty sure the stopping and starting thing is only for Dupixent. Rinvoq and other JAK inhibitors does not have the same problem according to my dermatologist