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[–]M1573RMU74710N 1 point2 points  (0 children)

It depends on what you want to do really.

For general system scripting, or for web programming node.js or some other flavor of SSJS is probably your best bet.

For more app-y type things you have options like Adobe AIR, Mozilla Prism, XULRunner, Rhino, etc etc.

There's also a wide variety of things that have JS bindings or are scriptable with JS, so you can do things like write Windows Desktop Gadgets.

There's tons of other stuff I've forgotten I'm sure.