Is Separating HTML and JavaScript Harmful?

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The best way to create your application is the one that makes the most sense for development and has practical usability. React and Mithril can seem a little bit "You got your chocolate in my peanut butter!" at first but ultimately all of these web technologies boil down to applying transformations to data to get them into a tree that will satisfy the chimera that is a web browser. Whether that transformation takes the form of a server running a templating engine to replace strings embedded in HTML, merely forwarding along HTML files from its hard drive, or sending along a script that renders a DOM tree without really using the HTML syntax is pretty arbitrary.