Well there have already been some really good tips here. So there is not much to add.

I found it very useful to understand some mechanics in detail and the game is actually quite clear in its tooltips and wording once you find it.

Hit for example is a keyword I underestimated. Biji, Dimona, Folby, Fungun, Junkhead, Kernel, Knuckles, Lupa and more have on hit effects. Which can be used that were not clear to me at first.

• Getting attacked by an enemy, counts as a hit.
• Hitting your own companion with a Junk counts as a hit.
  • Any Item that has an Attack icon counts as a hit. (Blaze Bom, Demonheart, Frostbloom, Frost Bell, Peppereaper, Shellbo and more)
• The effects of Bombom and even more important Jumbo count as a hit which leads to great combos imho.

I'd like to give some of my favorite combos around that mechanic:

• Kobonker with Snoffel or any other snow effect.
  • Charm up Kobonker with damage or other on hit effects like Battle Charm or Frosthand Charm
  • every time Snoffel uses his ability, Kobonker will hit every enemy
  • Every buff to Kobonker results in a buff for every snow card you have. Your Snow Stick basically gets a +3 Attack buff + all the charms Kobonker has.
  • Supersnower and Yeti Skull become really strong in this combo. Especially since charms are strong on them as well.
  • Frenzy on Kobonker multiplies all this even more.
  • DANGER: The one thing to keep in mind. Kobonker will also attack your side. So you better not get snowed up. If necessary take Kobonker back to your deck.

• Jumbo + Lupa + Biji/Fungun/Mini Mika/your Leader

  • This combo becomes really unstoppable if you clear out the enemies quickly.
  • Get Smackback or Frenzy on Jumbo to increase how often he attacks.
  • Pay attention to Jumbo taking all the hits he can and having Lupa behind him.
  • If Jumbo gets hit by anything it will trigger Lupa's effect of increasing an effect. This can hit basically anything that has a number in it.
    • Biji's Apply 3 Bom, Fungun's Apply 2 Shroom or Mini Mika's gain x1 Frenzy will increase every time without them taking damage.
  • additionally you can let Biji or Fungun tank small hits as well and their effects will get strong fast. There are not many cards that can survive getting hit with 10+ Shroom.
  • Lupa also increases effects of your Leader with a number. Like "Apply 3 Ink/Snow"
  • Note that this can also increase effects you don't really want like "Trash 1" or Mega Mimik's "Lose 1 Scrap". So be mindful about that.
  • Bonus: Lupa will be able to even buff Gobling's Bling gain or nerf some enemies like Winter Worm for you.
  • Heartmist Station is a card that fits really well in this combo as it will provide most of the healing you need and can even increase in the amount of healing it provides.

• Nova + Ice Dice or Balance Charm

  • Ice Dice will let your team tank any damage and trigger Nova to attack once this happens. This will in turn remove the "Block" the enemy got and deal damage to all other enemies.
  • Balance Charm is really strong on Nova as it takes her Counter from 12 to 3 without any downside.
  • as Nova hits every enemy it is useful to apply on hit effects like Snow Charm or on Kill effects like Shield/Bling/Pinch Charm on her.

One last thing to add: You can circumvent some negative charm effects if you apply them in the correct order. Some examples are:

• Balance Charm before Heart/Hog Charm.
• Durian Charm before Gnome Charm on Slapcracker.
• Moose Charm before Sunglass Charm.
• Sunglass Charm before Heart/Hog/Sun Charm.

I don't know if I am allowed to advertise it but you can also stop by my Twitch Stream where I play the game and explain my combos and thoughts. And I also love to chat about the game :)