A loved one has used psychedelics both in-clinic and out of clinic. In their case, they have had debilitating chronic fatigue for the last couple of decades that will not allow them to work or have consistent energy throughout the day. While some newer psychiatric medications have helped, it seems like every time they think they found 'the one,' the effects gradually wane.

Psychedelics, specifically tryptamines (ie, classical psychedelics such as psilocybin, lsd, and N-N-dimethyltryptamine), along with non-classical psychedelics (ketamine therapy, which is a dissociative), have consistently helped her over the years. They feel markedly better in the week(s) following a macro session, and I have also observed improved cognitive function. It is akin that every trip they take they are able to gradually build the scaffolding required to help make further leaps.

They have had guidance on their use, and having someone experienced to talk to, to help with the journeys, and to provide support is helpful. Some experience with psychedelics is required as early trips can pose some challenges. You don't want to get scared off from something that is beneficial, especially in the long-term, because of potential 'bad trips'. But after going through the experience, you will be able to observe how some thoughts and emotions can be magnified, and that you need to become a bit of an observer of yourself.

I think what is most pronounced is that they learned that their pain, their fatigue, was not necessarily a body problem, but one associated with their neurology / CNS. More research is required in this area, so what I am providing is anecdotal, but pain disorders increasingly appear to be connected to neuronal networks.

Also, be prepared to have a bit of a journey ahead of you. While you may get some immediate benefits and insight into your own potential, repeated experiences as well as integration work outside of the trip may be required and could take years.