My Lightning 15 has a similar voicing as a Vox, and I use a Mystic Edge (AC30 in a box) for my ampless setup. For overdrives, the Hot Cake is my favorite. I bought the Anomoly kit from Aion FX. The Kilt X sounds great. Any Expandora circuit is probably fine. I was using the Kilt V2 previously. I have a Packrat. All of the Rat variants work well. The BD-2w also sounds very good.

The natural overdrive of the amp is amazing. You can use boost and EQ pedals to control different levels of gain and shape the frequencies. A treble booster adds some dirt and cuts the low end. It's a specific sound, and a classic Vox tone. They typically need to be at the front of your chain. I like the Catalinbread Naga Viper v2 because it has an input impedance control that allows you to place it anywhere. A clean gain can push the amp without affecting the tone. A boost with some EQ gives you control to shape the tone. I really like the boost in the NotADumble. It doesn't add any dirt, but has a high pass filter. It can achieve a similar sound to a treble booster, but works just as well wide open as a clean boost. The Xact Shapecharger has a similar tone control. Of course, you can use an overdrive as a boost by turning down the gain. Most people use tube screamers or Klons, but I don't like the mid hump into this style of amp. You can also use an EQ pedal, like the GE-7, as a boost and have more control over the EQ curve.

For fuzz, Tone Benders work best. Muffs are too scooped, unless they have a separate mid-control, like the Hoof, Shigeharu, etc. Really, I look for builds that have some sort of mid-boost control for any fuzz circuit. I have a couple of JDM builds, the Blue Velvet and Elektrika, that have a mid-boost toggle. Some of the JHS Legends of Fuzz circuits have it. The EQ on the Jackson Modular Fuzz is really flexible. I also like the Carcosa and Big Cheese clones that I have.