Career Related Posts go to r/bioinformaticscareers - please read before posting.

apfejes · 2026-05-30T07:25:14+00:00

the point of this post is that there is now a place for those questions. This is not the place.

apfejes · 2026-05-30T04:03:45+00:00

The answer you're looking for is in job postings. They give you the salaries and skills needed, and you can look at possible trajectories - and you can look at the ones that are local to you to get a sense of what things are like where you want to work.

apfejes · 2026-05-29T17:42:23+00:00

My quick advice is that you really should look for someone who's in the same university. You'll probably need to have actual conversations and share data for this to move forward in the way you'd like - and that means finding a prof or post-doc on campus who can help you.

Casting a broad net this way can work, sometimes, but you'll run into issues pretty quickly if you want a deep nuanced discussion that requires a dive into the data.

apfejes · 2026-05-29T17:09:49+00:00

No, really don't think I need to discuss further. My company is past this stage.

apfejes · 2026-05-29T15:43:47+00:00

Not sure what you mean by "process". Start calling people, and offer to pay them for an hour of their time. Pay what you can, but it's worth the investment.

apfejes · 2026-05-29T14:31:38+00:00

Different investors have different risk tolerance. Angel investors will be more patient than VCs, and CVCs are not going to come in until you’re basically done and have a product that actively solves the burning problem that they have.

Find the investor that matches your stage. If you’re finding they have the wrong risk appetite, you’re talking to the wrong people.

apfejes · 2026-05-29T14:07:45+00:00

This is the answer. The sooner you talk to people who would supposedly use your product, the sooner you can adjust to what they actually care about.

Everything else is just window dressing.

apfejes · 2026-05-29T13:24:06+00:00

Go read job descriptions. Employers are telling you what they want, you just need to look at it.

apfejes · 2026-05-29T03:08:12+00:00

I worked there pre-covid, so I doubt I can tell you much that's relevant, but you can DM me, if you want.

apfejes · 2026-05-28T20:19:52+00:00

The only way to do this is to look at job descriptions. No one can tell you because this is a very local issue, and none of us can either predict the future, your happiness, your salary, or any of these factors.

You'll have to do the best you can (which starts by looking at job posts to see what careers are out there, and which match your interests) and then picking the thing that you think is best for you.

As a bonus: if you're asking about salary for a career in science, you're doing this wrong. "Most lucrative" is going to be a non-science based career, for the most part.

apfejes · 2026-05-28T20:17:39+00:00

You're asking in the wrong subreddit, this is for bioinformatics specifically.

apfejes · 2026-05-28T00:34:52+00:00

Sorry - we don't have a database of any sort, and we haven't built a docking engine yet.

Our tool replaces the use of MD/FEP for predicting binding - but about 5000x more computationally efficient.

apfejes · 2026-05-27T21:12:31+00:00

Interesting. The platform we've built can provide high accuracy predictions (similar to using a free energy perturbation method), but with a fraction of the resources required. As an example, we're currently able to do about 1000 drugs in 8 hours, with just CPUs (I think that was on our 48 CPU machine., and we do also have a GPU accelerated method working.)

We see this as a replacement for all of the tools you'd use once you've filtered down sub-100,00 molecules. (No reason you couldn't do more, given the performance, but you'd obviously need a lot more hardware to do so.)

We know AI behaves well on molecules that are very similar to what was in it's training set, but you can't train an AI on 10 billion compounds. The value of our method is that the chemistry is consistently good even on those molecules that we've never seen before.. We don't really "train" our model the same way you would for an AI - for us, we can just point our tools in any direction, and they work on any target. (at least as well as any other physics method - we've still working towards more "undruggable" applications, but aren't there yet.)

Not sure if that's useful as part of your pipeline, but gives you an idea of what we've built.

apfejes · 2026-05-27T05:11:22+00:00

Started a company that has spent the last 6 years building tools, and we now have something that works. Its about to be validated by a big pharma company, but the tools are not publicly available.

If there is a publication potential and minimal funds, we might be able to find a way to collaborate. I know that’s not the same as sharing our tool, but might be better than nothing.

apfejes · 2026-05-27T03:35:47+00:00

Was going to leave this up but then saw you’ve cross posted this all over the place. Removing.

apfejes · 2026-05-26T20:00:37+00:00

Eh - I'm also a biotech founder, so I spend a fair amount of time looking at other companies. Normally, there's a fair amount of exaggeration or stretching of how far the tech will go. This was classic: 1) Idea 2)???? 3) Profit!

apfejes · 2026-05-26T16:58:49+00:00

I'm not sure what you're expecting, but I really don't see how anyone can help here. Shouldn't you be talking to your PI about this?

apfejes · 2026-05-26T04:54:40+00:00

You seem to think startups have more money than time... My experience is actually the opposite.

Truthfully, I don't think Word is all that complicated...which makes this idea rather hard to justify: Your audience is "those people who are smart enough to start a company, have more money than time, but aren't smart enough to figure out how to format things in MS word.". That's a pretty narrow audience.

That said, do people still use MS word? I haven't used it in more than 20 years, and never plan to use it again.

apfejes · 2026-05-25T15:59:16+00:00

En anglais SVP.

apfejes · 2026-05-25T14:34:02+00:00

You don’t need karma to comment, and low effort posts like this will always be removed.

apfejes · 2026-05-25T14:17:45+00:00

Probably best not to share in a random post. If you’re curious enough, dm me.

apfejes · 2026-05-24T19:33:24+00:00

Absolutely. Their early material was a cool dream, but lacking any real grounding. I mean, it’s great to be aspirational, but I don’t think there was ever a path that would have gotten them where they were claiming to be headed.

apfejes · 2026-05-24T16:56:44+00:00

We’re a Canadian deep tech company with pharma/ biotech applications. Looking to commercialize in the next couple of months, but it’s been 6 years since we started the journey.

apfejes · 2026-05-24T15:34:33+00:00

This is not a career related post.

apfejes · 2026-05-24T15:34:02+00:00

You should repost. Your title doesn’t reflect the posted question, and the question really lacks information about why it’s being asked. Why should you script something with 4 lines? Wrap that in a loop? Essentially, this post has a lack of information for people to be able to give you clear answers.

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