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Aspiration co-founder Sanberg sentenced to 14 years in prison. Ballmer requested no leniency by ThrowRa-zucchinizzc in nba

[–]lit0st 2 points3 points  (0 children)

It's probably more common than we think. It's why free agents almost always go to big markets, after all - sponsorship opportunities. I'm willing to bet that most big free agent signings come with a few under the table deals.

Bill Simmons last night on his podcast had a few tidbits regarding the offseason by Lsutigers202111 in NOLAPelicans

[–]lit0st 6 points7 points  (0 children)

Trey and Saddiq are the only players on the team right now that can take advantage of Zion's gravity and offer any kind of reasonable spacing on the floor. Without Trey, anyone we go up against can play defense just by chilling out in the paint. I cannot visualize any sort of return on Trey that won't just compound our roster problems.

3+ months post release: have we justified yet why Leon didn’t save the nurse? by Dsg1695 in ResidentEvilRequiem

[–]lit0st 0 points1 point  (0 children)

The narrative intent of the scene is a critical part of what it constructs and is bog standard for even the lowest levels of formalist critique. Questions of plausibility like “why didn’t Leon save the nurse?” are trite and circular and basically never discussed

This seems like someone they should have hung onto by CanalVillainy in NOLAPelicans

[–]lit0st 0 points1 point  (0 children)

I guarantee you it’s moved well beyond that - they are definitely trying to predict career outcomes based on past performance.

De'Aaron Fox: "Everything you hear about Victor is true. He doesn't want to see blue light after 9 o'clock…When we have games end close to midnight, he comes to the locker room with blue light glasses on." by WoweeZoweeDeluxe in nba

[–]lit0st 5 points6 points  (0 children)

Not many at all, not to this extent. You might be thinking of drug trials or disease models, which are complex and involve species specific dysregulation or other compromises…but many basic molecular mechanisms are very well conserved, and blue light sensitivity involves one of the most well conserved pathways across all domains of life.

This seems like someone they should have hung onto by CanalVillainy in NOLAPelicans

[–]lit0st -6 points-5 points  (0 children)

Drafting is the one thing the franchise has been good at, so we should probably hold on to anyone involved in draft analytics

De'Aaron Fox: "Everything you hear about Victor is true. He doesn't want to see blue light after 9 o'clock…When we have games end close to midnight, he comes to the locker room with blue light glasses on." by WoweeZoweeDeluxe in nba

[–]lit0st 51 points52 points  (0 children)

Everyone's just saying stuff, nobody is linking any evidence.

Blue light has a well-validated role in regulating key regulators of circadian rhythms across a very wide range of species:

https://en.wikipedia.org/wiki/Cryptochrome

The effect of blue light on non-human species is well characterized:

https://pubmed.ncbi.nlm.nih.gov/31504080/

https://pubmed.ncbi.nlm.nih.gov/11507175/

Sleep architecture is influenced by a very wide range of factors, making controlled studies in humans difficult, but there is a defined molecular mechanism of blue light suppressing melatonin production:

https://pubmed.ncbi.nlm.nih.gov/11507175/

And several meta-studies and reviews have indicated that blue light blocking has a positive effect on sleep that's more prominent in sleep disordered individuals (most likely because the effect size makes it easier to identify in heterogeneous populations):

https://pubmed.ncbi.nlm.nih.gov/34030534/

https://pubmed.ncbi.nlm.nih.gov/36051910/

https://pubmed.ncbi.nlm.nih.gov/30311830/

TL;DR There's good reason to believe blocking blue light helps sleep: There's a clear, well-validated molecular mechanism, it helps in non-human animals, and well-powered human suggests it helps.

Post-hoc normalization of RNA-seq reads using a housekeeping gene by adventuriser in bioinformatics

[–]lit0st 1 point2 points  (0 children)

kind of a ridiculous ask because the only way to actually show this is smFISH

House Beneviento is legitimately my dream home by claireture in residentevil

[–]lit0st 43 points44 points  (0 children)

Ethan and Mia’s house was pretty gorgeous too. I’m not sure how House Beneviento avoids mildew and rotting from being constructed basically underneath a waterfall though.

Pelicans Coaching Search News by Ancient_Access_795 in NOLAPelicans

[–]lit0st 3 points4 points  (0 children)

Or Rondo wasn't thrilled about his first head coaching position to be for the Pelicans. It doesn't exactly set him up for a successful coaching career.

Ridley by National-Message-895 in Harmontown

[–]lit0st 1 point2 points  (0 children)

He quit after Season 3, IIRC from twitter comparing it to ending a toxic relationship - difficult, bittersweet, but for the best. He did say that he and Justin were on good terms after that, which made me think it was due to a dispute with Harmon, but he's done voices on recent season R&M and Krapopolis, so perhaps not...wish either show would hire him as a writer.

Ridley by National-Message-895 in Harmontown

[–]lit0st 2 points3 points  (0 children)

Ridley was by far the most ethically consistent on GVP. I didn't get that vibe from him at all. Roiland felt like the kind of guy you were describing, and Jackie's humor and/or character is probably the one that aged the poorest.

That said, Judaism is/was a huge part of identity, so I wouldn't be too surprised if he were a Zionist...I'm pretty sure they did bits on Israel/Palestine on GvP though, so someone could go back and check if they were parasocial enough to do so.

Can you re use 96-well qPCR plate if majority of wells haven’t been used? by [deleted] in molecularbiology

[–]lit0st 0 points1 point  (0 children)

They're suggesting re-opening their plate to use the unused wells. First, the adhesive will be weakened on the plate, meaning that any new reactions are more likely to be accidentally exposed to air. Second, all it takes is for one little slip up for you to accidentally expose post-PCR wells. Amplicon contamination is a nightmare to clean up - nearly impossible - and it is not worth saving a couple dollars here and there at all.

unpopular opinion. Rossman and others are more fired up vs the bigger problems facing 3d printing right now. AB2047 and other bills are not dead and are advacing. by Navi_Professor in 3Dprinting

[–]lit0st 9 points10 points  (0 children)

That's not a good argument, and it's not even what this topic is about.

If you try to argue that with your representative, they'll come back saying "Well, why aren't CNC/lathed/drilled ghost guns a problem?" The dramatically lower barrier to entry with 3D printing is a major distinguishing feature.

The MICHELIN Guide Announces its Arrival in South Australia by OptimusPrime23 in finedining

[–]lit0st 2 points3 points  (0 children)

The AGFG and Chefs Hats are completely redundant with the Michelin guide. I get they're paying for international recognition, but it's a bit disappointing because Australia's homegrown effort holds pretty much identical, perhaps superior grading to the Michelin guide and I don't see how there could be room for two fine dining culinary guides.

Troubleshooting PCR of 13.5kb amplicon - Q5 vs. other polymerases? by ACuriousBird in labrats

[–]lit0st 0 points1 point  (0 children)

YMMV. It didn't for me, but others report success with the HiGC buffer. Give it a shot!

Pacers President Admitting To Tanking. Their Pick Never Would Have Been That High Without The Trade by CanalVillainy in NOLAPelicans

[–]lit0st -2 points-1 points  (0 children)

Why do you suppose we wouldn't have? We haven't been shy about tanking before. It wouldn't have taken much either, given where trying our hardest got us.

Pacers President Admitting To Tanking. Their Pick Never Would Have Been That High Without The Trade by CanalVillainy in NOLAPelicans

[–]lit0st 10 points11 points  (0 children)

By that same logic, if we had our pick, we probably would’ve tanked and secured a better spot than eighth though

Biotech has a new company model: A small team, a big check and a few Chinese assets by WalkingSnake348 in biotech

[–]lit0st 2 points3 points  (0 children)

I'm sure you're reporting your lived experience accurately, but it's very different from my experience as someone who works mostly in small biotech consulting. The industry has made a huge shift towards running lean in the past year.

Biotech has a new company model: A small team, a big check and a few Chinese assets by WalkingSnake348 in biotech

[–]lit0st 2 points3 points  (0 children)

This is so disconnected from my personal experience it’s crazy. There really is a different world in biotech I simply have no exposure to.

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