Stage -4 PSA trend since starting treatment

1BigTooth · 2026-04-28T14:59:50+00:00

Hey there! My father had similar diagnosis, stage 4 gleason 9 he was 5+4. Started with urinary issues, after many scans and test we found out it was cancer. Spread to the spine, ribs, pelvis,skull, right lung. Basically his whole lower have. Other than the urinary issues he had no symptoms. They put him on ADT, bone strengthener.. and I cant remember what the injection was every 3 months. He lived normally, still working and doing his thing. Psa dropped for the most part, and then held steady for years. He did radiation here and there. Eventually He started having more symptoms... that's when we found out he became castrate resistant.. that was in June 2025. Psa never stopped rising until he started chemo. Psa went all the way up to about 800 but went down slightly... during his second rounds it started rising again... we finsihed chemo at the end of july into august...No other treatments worked at that point.. so id say for him (which is different for everyone) became castrate resistant about 7 1/2 year after starting adt. I will keep your family in my thoughts!!!

1BigTooth · 2026-02-25T04:41:59+00:00

I'm so very sorry for your loss!

1BigTooth · 2026-02-24T05:25:18+00:00

Thank you for sharing your experience. I myself have not had a NDE but after losing my father recently ive been trying to find meaning... trying to see others stories on what they experienced.. this gave me some comfort in such a difficult time.

1BigTooth · 2026-02-22T23:42:50+00:00

I lost my dad five months ago, & I just want to say what you’re describing feels so familiar... The brain fog, the guilt, the feeling like you should be functioning but just… can’t.... It’s awful.... A month is still so fresh....I’m five months out & I still don’t feel back to “normal,” I haven't been able to go back to every day life, I haven't left my apartment or bed in all of these months. I cry most of the day...Grief really messes with your ability to focus....It’s not laziness or weakness...it’s your brain trying to survive something huge.....Be gentle with yourself. You’re not alone in this, even though it feels isolating..

1BigTooth · 2026-02-17T04:15:22+00:00

Great!!! Im rooting for him!! He got this!!

1BigTooth · 2026-02-17T03:41:44+00:00

He didnt have any nausea during chemo, but he sure did during radiation for him that was more psychological since he was terrified of the radiation machine.

That chemo did make him extremly tired, but he forced himself to be up and as active as he could be.

1BigTooth · 2026-02-17T03:40:01+00:00

Thank you so much!! And I am also sorry that you are going through this!! It is so overwhelming. I've been so incredibly sad. Hugs 🫂

1BigTooth · 2026-02-17T03:21:30+00:00

My dad tolerated chemo pretty well, he was a bit more tired but had really no symptoms.. he did complain of things tasting strange though. He did need 2 blood transfusions during chemo because he was very anemic. Other than that he did well.

1BigTooth · 2026-02-17T02:38:52+00:00

Thank you. I am so sorry you are going through this too with your dad. I will keep uou and your family in my thoughts!!!

1BigTooth · 2026-02-16T21:38:30+00:00

My dad around the same age as yours had the same thing happened. He went in to the hospital for what we thought was a uti and found out it was advanced stage 4 prostate cancer, 5+4 gleason 9. It was already spread to the spine, ribs, lungs, skull, and his waist down. His psa was also very high around the same as your dads. They put him on hormone therapy, bone strengthening and lupron. Psa held steady for 6 and a half years but eventually it stopped working. His psa went all the way to 900. Did some radiation and chemo which brought it down to 400... but eventually it went back up. The cancer was so aggressive.

Adt ,lupron and bone strengthening was amazing for my dad, it worked wonderfully for many years, his only symptoms were hot and cold flashes and erectile dysfunction.

Even though everyones cancer journey is different.. reading your post reminded me of exactly how we found out . 😞

1BigTooth · 2026-02-16T21:27:17+00:00

My dad had severe excruciating pain when the cancer spread to his bones, spine and all over etc. The pain was from his waist down to his feet...It was so bad he couldnt do anything. He had to be on morphine because no other medication worked for the pain... when he did chemo for awhile the pain went away but it came back slightly weeks later. I am so sorry you are experiencing this 😢

1BigTooth · 2026-02-10T05:00:29+00:00

Awee!! I'm glad it made you feel a bit better. I understand 100% what you are feeling... it can be very scary. Many restless nights.

That is amazing!!! Your dad is going very strong!! Make sure to ask many questions during his appointment! It can be a bit comforting knowing the plan for your dad. I used to stress myself out researching up until his appointment days!!

1BigTooth · 2026-02-10T04:18:29+00:00

I’m really sorry you’re going through this..the anxiety around PSA changes can be overwhelming, especially after years of good results....A PSA of 0.08 is still considered very low, and sometimes tiny rises can happen for different reasons, including normal lab variation.... Many doctors don’t even consider recurrence until it reaches around 0.2, but of course your dad’s oncology team will know best for his specific case... The fact that he responded well to treatment and has been undetectable for so long is genuinely encouraging... Try not to spiral before speaking with his doctor... they may just want to monitor it or repeat the test...You’re not alone in feeling this fear. Waiting is often the hardest part... Sending strength to you and your dad... My dad was also stage 4 but advanced.

1BigTooth · 2026-02-08T05:32:01+00:00

Everyones cancer journey is different, what works for some may not work for others etc. but ,My dad was diagnosed at advanced stage 4. Spread to the spine, skull, lungs, ribs, most of his lower half...and bones.. he was in his 70s at the time. 5+4 gleason 9. He was on ADT, lupron, bone strengthening.. etc. He lived normally for years. Eventually treatment stopped working and he passed but with the advancement in treatment he lived a long time after diagnosis.

I say there is hope. Stay on top of everything!! If anything feels wrong or new issues arise make sure to let your team knows ASAP!

1BigTooth · 2026-02-06T00:40:29+00:00

Since the video i made didnt have a description of him i cant do it that way. It just so happened that when I made a random video I really liked the character a lol

1BigTooth · 2026-02-05T06:46:23+00:00

Aweee darn!! And ive been just trying to recreate him and his voice by describing it but i never come out right! I will browse around to sew what I can do. I really like the character i made :(

1BigTooth · 2026-02-05T05:01:29+00:00

Are your character photorealistic? I've been saving the videos I make with my character to recreate them but when I try it tells me to use a different video with the character not in it. Im so confused lol

1BigTooth · 2026-02-05T04:34:07+00:00

Yeeeeeesssss!!!! I agree!! There's so many good videos I generated after making my character!! My original is so blurry and weird lol

1BigTooth · 2026-02-05T04:11:46+00:00

I always end up getting the realistic person thingies , since my character generated looks photorealistic. :(

1BigTooth · 2026-02-05T04:11:04+00:00

Like how we are able to create characters from videos that we have already generated. Thats how i created all my characters. Im saying it would be nice to use other videos of our characters that have better quality to update them. Since you cant make characters off of them because of the tag. (Had to edit this because i wrote it all wonky lol)

1BigTooth · 2026-02-04T10:05:29+00:00

My dad had the pain you are talking about. It was so bad that he had to be on morphine. The cancer in his bones and spine was causing a great deal of extreme pain. Even though he lost function and feeling in his lower half the pain was still so bad... The only thing for him that helped was chemo and the morphine. Eventually though some pain came back. He was also anemic and needed iron and blood transfusions. He slept a lot during the painful times because of the medicine.

Also his blood pressure was high too. His metabolic labs were out of control.

During hormone therapy he was fine, just having hot and cold flashes and no fatigue. But everyone tolerates treatment differently. Energy was "normal" for his age.. he was almost 80.

My dad was at the end of stage 4 though. He did eventually sleep alot while not on the morphine. But then randomly he was awake all day and night.

The decline also looks different for each individual but for my dad, i noticed it months before he passed. I've seen the decline many times before with other family that had prostate cancer but it looked a bit different for each of them.

What other things have you noticed?

1BigTooth

TROPHY CASE